明目蒺藜丸联合更昔洛韦眼用凝胶治疗流行性角结膜炎的疗效观察

目的 观察明目蒺藜丸联合更昔洛韦眼用凝胶治疗流行性角结膜炎的临床疗效。方法 选择2015年10月—2016年10月在济南市济钢医院治疗的142例流行性角结膜炎患者作为研究对象，根据随机对照原则将患者分为对照组（71例104眼）和治疗组（71例105眼）。对照组患者在结膜囊内滴入更昔洛韦眼用凝胶，1滴/次，4次/d；治疗组患者在对照组治疗的基础上口服明目蒺藜丸，1袋/次，2次/d。两组患者均持续治疗14 d。观察两组患者的临床疗效和复发率，同时比较两组的证候积分、视力水平、CSIS评分和临床症状消退时间。结果 治疗后，对照组和治疗组总有效率分别为90.38%、98.10%，复发率分别为10.58%、2.86%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的证候积分和CSIS评分均显著下降，视力显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组证候积分、视力和CSIS评分显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者临床症状消退时间显著短于对照组，两组比较差异具有统计学意义（P<0.05）。结论 明目蒺藜丸联合更昔洛韦眼用凝胶治疗流行性角结膜炎具有较好的临床疗效，可显著改善患者视力水平，且复发率低、安全性好，具有一定的临床推广应用价值。

Clinical observation of Mingmu Jili Pills combined with Ganciclovir Ophthalmic Gel in treatment of epidemic keratoconjunctivitis

Objective To observe the clinical efficacy of Mingmu Jili Pills combined with Ganciclovir Ophthalmic Gel in treatment of epidemic keratoconjunctivitis. Methods Patients (142 cases) with epidemic keratoconjunctivitis in Ji''nan Jigang Hospital from October 2015 to October 2016 were randomly divided into control (71 cases, 104 eyes) and treatment (71 cases, 105 eyes) groups. Patients in the control group were dropped into the conjunctival sac with Ganciclovir Ophthalmic Gel, 1 drop/time, four times daily. Patients in the treatment group were po administered with Mingmu Jili Pills on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy and recurrence rate were evaluated, and the syndrome scores, visual acuity, CSIS scores, and clinical symptom regression time in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment group were 90.38% and 98.10%, respectively, and the recurrence rates in the control and treatment group were 10.58% and 2.86%, respectively, there were differences between two groups (P<0.05). After treatment, the syndrome scores and CSIS scores in two groups were significantly decreased, but the visual acuity in two groups was significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the syndrome scores, visual acuity, and CSIS scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the clinical symptom regression time in the treatment group was significantly shorter than that in the control group, and there were differences between two groups (P<0.05). Conclusion Mingmu Jili Pills combined with Ganciclovir Ophthalmic Gel has good clinical curative effect in treatment of epidemic keratoconjunctivitis, can significantly improve the visual acuity of patients, with low recurrence rate and good safety, which has a certain clinical application value.