代谢组学在骨质疏松症中的应用进展

骨质疏松症好发于中老年人群,是一种危害巨大的全身代谢性骨骼疾病。代谢组学是近年来兴起的科学,可以对生物样本中的全部代谢产物进行定量测量分析,从而直观、全面地反映生物体内的代谢物变化。将代谢组学运用到骨质疏松症中或有一定优势,目前已成为研究热点之一。基于代谢组学在骨质疏松症中的应用,本文综述了将代谢组学运用于骨质疏松症的早期诊断及中药干预机制等方面的研究文献,初步总结部分可能可用于诊断骨质疏松症的特异性代谢标志物,展望代谢组学在骨质疏松症的中药干预机制研究及临床应用方面的前景。

Advances in the application of Metabolomics in osteoporosis

Osteoporosis often occurs in middle-aged and elderly people, it is a kind of harmful whole body metabolic skeletal disease. Metabolomics is the science that has arisen in recent years, which can carry out the quantitative measurement analysis to all metabolites in biological samples. Thus, it can directly and comprehensively reflect the metabolic changes in the organism. Applying metabolomics to osteoporosis has certain advantage, and now it has become one of the research hotspots. Based on the application of metabolomics in osteoporosis, this paper summarizes the literature on the application of metabolomics in the early diagnosis of osteoporosis and the intervention mechanism of Chinese herbal medicine, and summarizes some specific metabolic markers that may be used to diagnose osteoporosis. Prospects for the research and clinical application of metabolomics in the intervention mechanism of Chinese medicine for osteoporosis was also discussed.