| 槐定碱和氧化槐定碱对心脑血管疾病药理作用的研究进展 |
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| 引用本文： | 抗晶晶,刘晓宁. 槐定碱和氧化槐定碱对心脑血管疾病药理作用的研究进展[J]. 现代药物与临床, 2019, 42(4): 794-798 |
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| 作者姓名： | 抗晶晶 刘晓宁 |
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| 作者单位： | 黄河科技学院 医学院, 河南 郑州 450063,黄河科技学院 医学院, 河南 郑州 450063 |
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| 基金项目： | 河南省科技厅科技攻关项目（172102310208）；河南省教育厅自然科学计划项目（16A180046） |
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| 摘 要： | 槐定碱和氧化槐定碱是中药苦豆子中的主要活性成分，可能通过抗氧化、抗炎、抗细胞凋亡、调节钙循环等途径，表现出对心力衰竭、心肌梗死、脑缺血、脑缺血再灌注损伤等心脑血管疾病的良好防治效果。综述近年来槐定碱和氧化槐定碱对心脑血管疾病的防治作用及其作用机制的研究进展，为临床应用槐定碱和氧化槐定碱治疗心脑血管疾病提供参考。
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| 关 键 词： | 槐定碱 氧化槐定碱 心血管疾病 脑血管疾病 |
| 收稿时间： | 2018-08-16 |
Research progress in pharmacological effects of sophoridine and oxysophoridine on cardiovascular and cerebrovascular diseases |
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| KANG Jingjing and LIU Xiaoning. Research progress in pharmacological effects of sophoridine and oxysophoridine on cardiovascular and cerebrovascular diseases[J]. Drugs & Clinic, 2019, 42(4): 794-798 |
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| Authors: | KANG Jingjing and LIU Xiaoning |
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| Affiliation: | Department of Biochemistry, School of Medicine, Huanghe Science and Technology University, Zhengzhou 450063, China and Department of Biochemistry, School of Medicine, Huanghe Science and Technology University, Zhengzhou 450063, China |
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| Abstract: | Sophoridine and oxysophoridine are the essential components of traditional Chinese medicine Sophora alopecuroides L.Pharmacological research results showed that sophoridine and oxysophoridine were effective in preventing and treating cardiovascular and cerebrovascular diseases such as heart failure,myocardial infarction,cerebral ischemia and cerebral ischemia reperfusion injury through anti-oxidation,anti-inflammation,anti-apoptosis and regulating calcium circulation.This paper reviewed the effects and mechanisms of sophoridine and oxysophoridine on cardiovascular and cerebrovascular diseases,which can provide references for treatment of cardiovascular and cerebrovascular diseases with sophoridine and oxysophoridine. |
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| Keywords: | sophoridine oxysophoridine cardiovascular diseases cerebrovascular diseases |
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