| 6种人参属药材体外抗凝血活性与皂苷含量的相关性研究 |
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| 引用本文： | 舒盼盼,朱鹏飞,杨鑫龙,李璐茜,于未博,杨野,曲媛.6种人参属药材体外抗凝血活性与皂苷含量的相关性研究[J].中草药,2019,50(4):918-924. |
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| 作者姓名： | 舒盼盼 朱鹏飞 杨鑫龙 李璐茜 于未博 杨野 曲媛 |
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| 作者单位： | 昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续发展利用重点实验室, 云南 昆明 650500,云南农业大学农学与生物技术学院, 云南 昆明 650000,昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续发展利用重点实验室, 云南 昆明 650500,昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续发展利用重点实验室, 云南 昆明 650500,昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续发展利用重点实验室, 云南 昆明 650500,昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续发展利用重点实验室, 云南 昆明 650500,昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续发展利用重点实验室, 云南 昆明 650500 |
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| 基金项目： | 云南省科技计划项目重大科技专项（2018ZF014）；云南省环境保护项目（2014BI0012） |
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| 摘 要： | 目的分析不同功效的6种人参属药材提取物的体外凝抗血活性差异。方法采用凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(FIB)实验,探讨6种人参属药材提取物抗凝血活性的差异性;分析其抗凝血活性与皂苷含量的相关性。结果竹节参、珠子参及三七可显著延长PT、APTT,降低FIB水平,呈现明显的量效关系;而人参、西洋参及屏边三七无显著变化。竹节参、珠子参提取物的抗凝血活性明显强于三七提取物。6种人参属药材中人参皂苷含量与其抗凝血活性的相关性分析表明,PT与人参皂苷Rb2含量呈现显著的正相关;且人参皂苷Rb2可显著延长PT、APTT。结论 6种人参属药材抗凝血活性存在差异,且抗凝血活性与人参皂苷Rb2含量相关。
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| 关 键 词： | 人参属 竹节参 珠子参 三七 人参 西洋参 屏边三七 人参皂苷 抗凝血活性 相关性 凝血酶原时间 活化部分凝血酶原时间 纤维蛋白原 |
| 收稿时间： | 2018/9/25 0:00:00 |
Correlation between anticoagulant activity and ginsenoside content in six Panax species |
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| SHU Pan-pan,ZHU Peng-fei,YANG Xin-long,LI Lu-xi,YU Wei-bo,YANG Ye and QU Yuan.Correlation between anticoagulant activity and ginsenoside content in six Panax species[J].Chinese Traditional and Herbal Drugs,2019,50(4):918-924. |
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| Authors: | SHU Pan-pan ZHU Peng-fei YANG Xin-long LI Lu-xi YU Wei-bo YANG Ye and QU Yuan |
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| Institution: | School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Sustainable Development Panax notoginseng Resources, Kunming 650500, China,College of Agronomy and Biotechnology, Yunnan Agricultural University, Kunming 650000, China,School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Sustainable Development Panax notoginseng Resources, Kunming 650500, China,School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Sustainable Development Panax notoginseng Resources, Kunming 650500, China,School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Sustainable Development Panax notoginseng Resources, Kunming 650500, China,School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Sustainable Development Panax notoginseng Resources, Kunming 650500, China and School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Sustainable Development Panax notoginseng Resources, Kunming 650500, China |
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| Abstract: | Objective To analyze the effects of different extracts from six Panax species on coagulation properties in vitro. Methods The prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) assays were used to investigate the difference of anticoagulant activity of extracts and the correlation between anticoagulant activity and saponin content in six Panax species. Results The results showed that Panax japonicus, P. japlcus, and P. notoginseng significantly prolonged PT and APTT, and reduced FIB content in a dose-dependent manner, while P. ginseng, P. quinquefolius, and P. stipuleanatus had no significant effects. Compared with the P. notoginseng group, the anticoagulant activity of the extracts of P. japonicus and P. japlcus was significantly stronger than that of P. notoginseng. Correlation analysis of ginsenoside content and anticoagulant activity showed that PT presented a positive correlation with ginsenoside Rb2 significantly. Ginsenoside Rb2 significantly prolonged PT and APTT. Conclusion In summary, and anticoagulant activity is related to ginsenoside Rb2 content. |
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| Keywords: | Panax L Panax japonicus C A Mey Panax japlcus C A Mey var major (Burk ) C Y Wu et K M Feng Panax notoginseng F H Chen Panax ginseng C A Meyer Panax quinquefolius L Panax stipuleanatus H T Tsai et K M ginsenoside fenganticoagulant activity correlation analysis prothrombin time activated partial prothrombin time fibrinogen |
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