白及合剂联合制霉素片治疗念珠菌性食管炎肝郁脾虚型患者的疗效观察

[目的] 观察白及合剂联合制霉素片治疗念珠菌性食管炎肝郁脾虚型患者的临床疗效。[方法] 70例肝郁脾虚型念珠菌性食管炎患者随机分为两组（n=35），对照组患者应用氟康唑胶囊，观察组应用白及合剂联合制霉素片，疗程2~4周。比较两组患者治疗前后中医证候评分变化、胃镜结果、综合疗效及不良反应等情况。[结果] 治疗2周后观察组反酸/烧心、胃脘/胁肋痛、胸骨后灼痛、食少纳呆、腹胀、大便异常、舌质、舌苔、急躁易怒/抑郁、善太息、嗳气评分及总评分较治疗前显著下降（P<0.05）。治疗2周后对照组反酸/烧心、胃脘/胁肋痛、胸骨后灼痛、食少纳呆、腹胀、大便异常、舌质、舌苔、急躁易怒/抑郁评分及总评分较治疗前显著下降（P<0.05）。观察组在改善胃脘/胁肋痛、胸骨后灼痛、食少纳呆、腹胀、大便异常、舌质、舌苔、急躁易怒/抑郁、善太息等方面优于对照组（P<0.05）。观察组患者的胃镜疗效及综合疗效均显著优于对照组（P<0.05）。[结论] 白及合剂联合制霉素片能显著改善念珠菌性食管炎肝郁脾虚型患者的临床症状，抗真菌疗效确切，且无明显毒副作用。

Clinical observation of Baiji Mixture combined with nystatin tablets in the treatment of candidal esophagitis with liver depression and spleen deficiency

[Objective] To observe the clinical efficacy of Baiji Mixture combined with nystatin tablets in the treatment of candidal esophagitis with liver depression and spleen deficiency. [Methods] The 70 patients with candidal esophagitis of liver depression and spleen deficiency were randomly divided into two groups (n=35). The control group was treated with fluconazole capsule,while the observation group was treated with Baiji Mixture combined with nystatin tablets for 2-4 weeks. The changes of TCM syndrome scores,gastroscopy results,comprehensive efficacy and adverse reactions were compared between the two groups before and after treatment. [Results] After 2 weeks of treatment,the scores of acid reflux/heartburn,epigastric/hypochondriac pain,post-sternal burning pain,diet deficiency,abdominal distension,abnormal stool,tongue,tongue coating,irritability/depression,frequent sighing,belching and total score in the observation group were significantly lower than those before treatment (P<0.05). After 2 weeks of treatment,the scores of acid reflux/heartburn,epigastric/hypochondriac pain,post-sternal burning pain,dietary deficiency,abdominal distension,abnormal stool,tongue,tongue coating,irritability/depression and total score in the control group were significantly lower than those before treatment (P<0.05). The observation group was superior to the control group in improving epigastric/hypochondriac pain,post-sternal burning pain,diet deficiency,abdominal distension,abnormal stool,tongue,tongue coating,irritability/depression,and frequent sighing (P<0.05). The gastroscopic efficacy and comprehensive efficacy of the observation group were significantly better than those of the control group (P<0.05). [Conclusion] Baiji Mixture combined with nystatin tablets can significantly improve the clinical symptoms of patients with candidal esophagitis of liver depression and spleen deficiency,with definite antifungal effect and no obvious toxic and side effects.