| 苦参碱类生物碱免疫促进作用的研究进展 |
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| 引用本文： | 张明发,沈雅琴. 苦参碱类生物碱免疫促进作用的研究进展[J]. 现代药物与临床, 2019, 42(3): 579-585 |
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| 作者姓名： | 张明发 沈雅琴 |
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| 作者单位： | 上海美优制药有限公司, 上海 201204,上海美优制药有限公司, 上海 201204 |
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| 摘 要： | 苦参碱类生物碱具有广泛的生物活性，如保护心、肝、肺、肾、脑、血管作用，对心脏有正性肌力、负性频率、抗心律失常作用，还有升高白细胞，平喘，抗溃疡，抗肝纤维化以及镇静、催眠、镇痛等中枢神经药理作用，也具有抗肿瘤、免疫调节、抗菌、抗病毒、抗炎等药理作用。苦参碱类生物碱对机体免疫功能具有双向调节作用，在高剂量时表现为免疫抑制作用，在低剂量时表现为免疫促进作用。综述氧化苦参碱、苦参碱、槐定碱和槐果碱的免疫促进作用，为进一步开发研究和临床应用提供参考。
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| 关 键 词： | 苦参碱类生物碱 氧化苦参碱 苦参碱 槐定碱 槐果碱 免疫促进作用 |
| 收稿时间： | 2018-11-29 |
Research advances on immunostimulation of matrine-type alkaloids |
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| ZHANG Mingfa and SHEN Yaqin. Research advances on immunostimulation of matrine-type alkaloids[J]. Drugs & Clinic, 2019, 42(3): 579-585 |
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| Authors: | ZHANG Mingfa and SHEN Yaqin |
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| Affiliation: | Shanghai Meiyou Pharmaceutical Co. Ltd., Shanghai 201204, China and Shanghai Meiyou Pharmaceutical Co. Ltd., Shanghai 201204, China |
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| Abstract: | Matrine-type alkaloids have awidespread bioactivities,including protection of heart,liver,lung,kidney,brain and blood vessel,andtheeffectsofpositiveinotropism,negativechronotropismandantiarrhythmiaonheart,andpromotingleukocytes,antiasthma,antiulcer,anti-fibrogenesisinliver,andcentralsuppressionofsedation,hypnogenesis,analgesia,andantitumor,immunoregulation,anti-bacteria,antivirus and anti-inflammation effect.Matrine-type alkaloids have two-way immunoregulation.Matrine-type alkaloids show immunosuppressant effects in high dosage,and immunostimulant effects in low dosage.The literatures on immunostimulation of oxymatrine,matrine,sophoridine,sophocarpine have been reviewed for the development research and clinical use. |
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| Keywords: | matrine-type alkaloids oxymatrine matrine sophoridine sophocarpine immunostimulation |
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