益肾清利活血泄浊方延缓慢性肾脏病进展回顾性研究

目的观察益肾清利活血泄浊方对慢性肾功能不全患者肾功能的影响。方法回顾性分析2018年1-5月江苏省中医院肾内科慢性肾脏病5期(CKD5)的患者,收集患者CKD3~5期的临床资料,按照治疗方案分为基础治疗组(对照组,52例),基础治疗+中药组(观察组,56例),比较两组治疗过程中血清肌酐(SCr)、尿素氮(BUN)、肾小球滤过率(eGFR)、血红蛋白(HGB)、白蛋白(ALB),记录两组患者CKD3期进入CKD5期的时间,通过Kaplan-Meier生存曲线观察两组患者进入肾脏终点事件(CKD5期)时间。结果与对照组比较,观察组CKD3~4期时间及CKD4~5期时间延长(P<0.05),患者肾脏生存时间延长(P<0.05),5年、10年生存率升高(P<0.01,P<0.05)。两组SCr、BUN、eGFR、HBG、ALB水平比较,差异无统计学意义(P>0.05)。结论益肾清利活血泄浊方能有效延缓CKD3~4期患者肾功能进行性减退。

Clinical Retrospective Analysis of Yishen Qingli Huoxue Xiezhuo Recipe on Delaying the Progression of Chronic Kidney Disease

Objective To observe the effect of Yishen Qingli Huoxue Xiezhuo Recipe ( YQHXR) on renal function in patients with chronic kidney disease ( CKD). Methods Clinical data of patients with CKD stage 3 -5 in renal division of Jiangsu Province Hospital of Chinese Medicine from January 2018 to May 2018 was analyzed retrospectively. Patients were assigned to routine therapy group ( control group,52 cases) and routine therapy combined with YQHXR group ( observation group,56 cases) according to the therapeutic regime. Changes of serum creatinine ( SCr),blood urea nitrogen ( BUN),estimated glomerular filtration rate ( eGFR),hemoglobin ( HGB) and albumin ( ALB) were determined. Kaplan -Meier survival curve was used to observe the time of entering renal endpoint event ( CKD5 stage). Results Compared with control group, the progression of CKD stage 3 -4 and CKD stage 4 -5 were delayed in the observation group(P <0. 05), the survival time of CKD patients was also prolonged(P <0. 05), the 5 -,10 - year survival rates were increased in the observation group(P < 0. 01,P <0. 05). There was no significant difference in serum SCr,BUN, eGFR,HBG and ALB between the two groups(P >0. 05). Conclusion YQHXR could delay the loss of kidney function in patients with CKD stage 3 -4.