MiR-183 家族在肝癌筛查中的作用

目的：系统评价肝癌循环系统及（或）组织中 miR-183 家族对肝癌的诊断价值。方法：计算机检索万方数据库、中国生物医学服务系统、中国知网、PubMed、Medline、Embase、Cochrane 临床试验数据库等，于 2010年 1 月—2016 年12 月发表的关于肝癌中（组织或循环系统）的 miR-183 家族（包括 miR-182、miR-96、miR-183）表达的文章，用 Sstate12.0 计算合并后的敏感性、特异性、阳性似然比、阴性似然比、诊断比值比以及合并的受试者工作曲线（SROC）。结果：经过筛选共得到 6 篇相关文献，分析 3 种不同 miR-183 家族成员或来源的指标，其中肝癌 497 例，各类对照组共 736 人。因为研究之间存在异质性，采用随机效应模型进行合并。合并后的灵敏度、特异度、阳性似然比、阴性似然比、诊断比值比及合并后的 ROC 面积（含 95%CI）分别为 0.76（0.70,0.84）、0.83（0.79,0.87）、4.64（3.6,5.97），0.27（0.20,0.36）、17.22（11.12,26.67）及 0.88（0.85,0.90）。结论：miR-183 家族对肝癌具有一定诊断价值，可能作为肝癌的新型肿瘤标志物。

Effect of miR-183 Family in Screening for Hepatoma Carcinoma

Objective To systematically evaluate the diagnostic value of miR- 183 family in hepatoma carcinoma. Methods The computer was used to search the document about the expression of microRNA-183 family (including miR- 182 , miR- 96 and miR- 183 ) in hepatocellular carcinoma (tissue or circulatory system) from WanFang data, China Biological Medical Service System, CNKI, PubMed, Medline, Embase and Cochrane Clinical Trials Database from January 2010 to December 2016 . The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area of SROC were analyzed. Results Six relative articles were finally found, and three indicators different mir- 183 family members or sources were analyzed.The hepatoma carcinoma patients was 497 cases and the controls was 736 cases. Because of the heterogeneity between the studies, a random effect model was used to merge the studies. The pooled sensitivity, speci?city, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area of SROC were 0.76 (0.70,0.84), 0.83 (0.79,0.87), 4.64 (3.6,5.97), 0.27 (0.20,0.36), 17.22 (11.12,26.67) and 0.88 (0.85,0.90), respectively.