| 涤痰汤对帕金森病大鼠行为学和氧化应激反应的影响 |
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| 引用本文： | 丁宏娟,何建成,王文武. 涤痰汤对帕金森病大鼠行为学和氧化应激反应的影响[J]. 上海中医药杂志, 2009, 43(3): 63-65 |
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| 作者姓名： | 丁宏娟 何建成 王文武 |
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| 作者单位： | 上海中医药大学基础医学院,上海,201203;上海中医药大学基础医学院,上海,201203;上海中医药大学基础医学院,上海,201203 |
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| 基金项目： | 国家自然科学基金,上海市教育委员会资助项目,上海市重点学科建设项目 |
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| 摘 要： | 目的观察涤痰汤对帕金森病（PD）大鼠行为学和氧化应激反应的影响。方法运用6-羟基多巴胺立体定向注射复制PD大鼠模型。将PD模型大鼠随机分为模型组与化痰组;另设正常组和假手术组,分别给予相应处理,共14d。观察各组治疗前后大鼠旋转圈数,测定大鼠中脑黑质纹状体活性氧、丙二醛、谷胱甘肽含量,谷胱甘肽过氧化物酶、超氧化物歧化酶的活性。结果与模型组比较,化痰组大鼠旋转圈数、活性氧及丙二醛含量明显减少,谷胱甘肽含量明显增多,谷胱甘肽过氧化物酶及超氧化物歧化酶活性明显增高,差异均有统计学意义（P〈0.05）;化痰组各氧化应激指标与正常组和假手术组之间的差异有统计学意义（P〈0.05）。结论涤痰汤能明显改善PD大鼠旋转行为,减轻其黑质纹状体氧化应激损伤。
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| 关 键 词： | 帕金森病 涤痰汤 行为学 氧化应激 |
Effects of Ditan Decoction on Behavioristics and Oxidative Stress Reaction of Rats with Parkinson's Disease |
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| DING Hong-juan HE Jian-cheng WANG Wen-wuShanghai University of Traditional Chinese Medicine. Effects of Ditan Decoction on Behavioristics and Oxidative Stress Reaction of Rats with Parkinson's Disease[J]. Shanghai Journal of Traditional Chinese Medicine, 2009, 43(3): 63-65 |
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| Authors: | DING Hong-juan HE Jian-cheng WANG Wen-wuShanghai University of Traditional Chinese Medicine |
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| Affiliation: | (Shanghai University of Traditional Chinese Medicine) |
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| Abstract: | Objective To study the effects of Ditan Decoction on behavioristics and oxidative stress reaction of rats with Parkinson's disease.Methods PD model rats were established through stereotoxic microinjection of 6-OHDA.The PD rats were randomized into model group and treatment group;and normal group and sham group were also established and given corresponding treatments,all with a course of 14 days.The behavioristics(number of rotation) was observed before and after treatment;moreover,the contents of active o... |
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| Keywords: | Parkinson's disease Ditan decoction behavioristics oxidative stress |
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