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| 结直肠癌组织中基质金属蛋白酶-10的表达及临床意义 | |
| 引用本文： | 马顺茂,贾漪涛,刘红磊,杜芸,王永军,李中信. 结直肠癌组织中基质金属蛋白酶-10的表达及临床意义[J]. 中国全科医学, 2011, 14(2) |
| 作者姓名： | 马顺茂 贾漪涛 刘红磊 杜芸 王永军 李中信 |
| 作者单位： | 1. 河北医科大学附属华北石油管理局总医院,河北省任丘市,062552 2. 河北省人民医院肿瘤科 3. 河北医科大学第四医院 |
| 基金项目： | 河北省卫生厅重点课题计划(07109) |
| 摘 要： | 目的研究基质金属蛋白酶-10(MMP-10)在结直肠癌组织中的表达情况,分析其与临床病理特征的关系及其在转移中的意义。方法应用免疫组化法检测68例结直肠癌和12例正常黏膜组织MMP-10的表达,并分析其表达与临床病理参数的关系。结果 68例结直肠癌组织中的MMP-10阳性表达率为69.1%,对照组均无阳性表达。伴有淋巴结转移者MMP-10阳性表达率为82.9%,无淋巴结转移者为54.5%,差异有统计学意义(P<0.05);腹腔转移阳性者阳性表达率为91.7%,阴性者为64.3%,差异有统计学意义(P<0.05);TNM分期Ⅰ~Ⅱ期者阳性表达率为60.6%,Ⅲ~Ⅳ期者为82.9%,差异有统计学意义(P<0.05);侵透浆膜者阳性表达率为77.8%,未侵透浆膜者为52.2%,差异有统计学意义(P<0.05)。免疫组化染色示正常黏膜MMP-10呈阴性表达;原发肿瘤组织呈阳性表达;淋巴结转移灶中MMP-10的表达强度与原发灶中一致。肝转移患者的转移灶周围肝组织均强烈表达,而转移灶本身表达较原发灶弱。结论 MMP-10在结直肠癌组织中高表达。MMP-10阳性表达与肿瘤的发生、侵袭和转移密切相关,在腹腔转移中起重要作用,... |
| 关 键 词： | 基质金属蛋白酶类 结直肠肿瘤 肿瘤转移 |
Expression of Matrix Matalloproteinase-10 in Colorectal Carcinoma and Its Clinical Significance |
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| MA Shun-mao,JIA Yi-tao,LIU Hong-lei,et al.. Expression of Matrix Matalloproteinase-10 in Colorectal Carcinoma and Its Clinical Significance[J]. Chinese General Practice, 2011, 14(2) | |
| Authors: | MA Shun-mao JIA Yi-tao LIU Hong-lei et al. |
| Affiliation: | MA Shun-mao,JIA Yi-tao,LIU Hong-lei,et al.Department of General Surgery,Huabei Oil Field General Hospital of Hebei Medical University,Renqiu 062552,China |
| Abstract: | Objective To explore the expression of matrix matalloproteinase-10(MMP-10) in colorectal carcinoma and its clinical significance.Methods The expressions of MMP-10 in 68 colorectal carcinoma tissues and 12 normal colonic mucosa specimens were detected using immunohistochemical methods,and its relationship with clinical pathological parameters were analyzed.Results The positive rate of MMP-10 in 68 primary colorectal carcinoma tissues was 69.1%,while no expression of MMP-10 was detected in the normal colonic ... |
| Keywords: | Matrix metalloproteinases Colorectal neoplasms Neoplasms metastasis |
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