颈动脉粥样硬化与高血压患者脉压及脉压指数的相关性研究

【目的】探讨高血压病患者颈动脉粥样硬化与脉压（PP）和脉压指数（PPI）的相关性。【方法】选取高血压患者162例，所有患者采用彩色多普勒超声测定颈动脉内中膜厚度（IM T ），并依据IM T分为颈动脉粥样硬化114例（硬化组）和颈动脉正常48例（正常组），对患者进行动态血压监测并计算PP和PPI ，并与彩色多普勒超声结果对比分析。【结果】硬化组患者收缩压（SBP）、平均动脉压（MBP）、脉压（PP）和PPI显著高于正常组，差异均有统计学意义（ P ＞0．05）。PP＞60 mmHg患者的IMT（1．37±0．43 cm）显著高于PP≤60 mmHg患者的IMT（0．83±0．12 cm），差异具有统计学意义（ P ＜0．05）。PP与PPI均呈现正相关性（正常组：r ＝0．902，P ＝0．001；硬化组：r ＝0．894，P ＝0．002）。【结论】颈动脉粥样硬化和PP与PPI密切相关性，通过联合检测，对临床预防高血压合并颈动脉硬化具有重要意义。

Research on the Correlation of Carotid Atherosclerosis with Pulse Pressure and Pulse Pressure Index in Patients with Hypertension

[Objective] To explore the correlation of carotid atherosclerosis with pulse pressure （PP） and pulse pressure in-dex（PPI） in patients with hypertension .[Methods] Totally 162 patients with hypertension were selected .Color Doppler ul-trasound was used to measure carotid intima-media thickness（IMT） in all patients .According to IMT ,all patients were divid-ed into carotid atherosclerosis group（n=114） and carotid normal group（n=48） .The dynamic blood pressure was monitored . PP and PPI were calculated and compared with the results of color Doppler ultrasound .[Results] Systolic blood pressure （SBP） ,mean arterial blood pressure （MBP） ,PP and PPI in carotid atherosclerosis group were markedly higher than those in normalcarotidgroup,andtherewassignificantdifference（P〈0.05）.IMTinpatientswithPP〉60mmHgwas1.37±0.43 cm ,which was markedly higher than that in patients with PP 〈60mmHg（0 .83 ± 0 .12cm） ,and there was significant differ-ence（ P〈0 .05） .PP and PPI showed a positive correlation （normal carotid group：r=0 .902 ,P=0 .001;carotid atheroscle-rosis group ：r=0 .894 ,P=0 .002） .[Conclusion]Carotid atherosclerosis is closely related with PP and PPI .The combination detection is important to prevent hypertension with carotid atherosclerosis .