三种新辅助化疗方案在宫颈癌治疗中的应用和比较

目的 通过比较3种宫颈癌新辅助化疗方案的疗效及化疗毒副反应,以期找到宫颈癌的最佳新辅助化疗方案.方法 将102例Ⅰ b～Ⅱb宫颈癌患者术前随机分为3组,接受不同化疗方案化疗1～2个疗程,其中采用顺铂+5-氟尿嘧啶(PF)组为43例;顺铂+紫杉醇(Pr)组为26例;顺铂+平阳霉素(PB)组为33例.患者于化疗后10～14天行宫颈癌根治术.结论 3组化疗方案总有效率达89.2%,其中顺铂+5-氟尿嘧啶组疗效与其它两组无差异(P>0.05).而化疗不良反应发生率明显低于其它两组(P<0.05).结论新辅助化疗能有效的控制官颈局部病灶,顺铂+5.氟尿嘧啶是宫颈癌新辅助化疗的最佳方案.

Applications of three neoadjuvant chemotherapy Schemes in cervical cancer

Objective To explore a best scheme in neoadjuvant chemotherapy of cervical cancer. Methods one hundred and two patients with stage Ib ～ II b of cervical cancer were randomized into 3 groups. Group A (43 cases) received the scheme of cisplatin and 5-Fluorouracil(5-Fu); Group B (26 cases) received the scheme of cisplatin and Taxol; Group C (33 cases) received the scheme of cisplatin and Bleomycin. After 10～ 14 days, they were managed by radical hysterectomy and pelvic lymphadenec-tomy. Results The total effective rate was 89. 2%. There were no difference in curative effect between cisplatin and 5-FU scheme and other two schemes. But the incidence of adverse effect of cisplatin and 5-FU scheme was much lower than other two schemes. Conclusion Cisplatin and 5-FU scheme is the best scheme in neoadjuvant chemotherapy of cervical cancer.