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| 单靶点与多靶点联合毁损术治疗阿片类药物成瘾的长期疗效 | |
| 引用本文： | 常崇旺,王学廉,葛顺楠,吴鹤鸣,赵海康,常晓赞,王鹏,方伟,李敏,李定君,明扬,汪崇琦,曾彦萍,汪鲁刚,蔡美玲,尹忠民,吴静,卢旺盛,孙艳杰,韩凌,李殿友,陈美君,高国栋. 单靶点与多靶点联合毁损术治疗阿片类药物成瘾的长期疗效[J]. 中国微侵袭神经外科杂志, 2011, 16(2): 51-55 |
| 作者姓名： | 常崇旺 王学廉 葛顺楠 吴鹤鸣 赵海康 常晓赞 王鹏 方伟 李敏 李定君 明扬 汪崇琦 曾彦萍 汪鲁刚 蔡美玲 尹忠民 吴静 卢旺盛 孙艳杰 韩凌 李殿友 陈美君 高国栋 |
| 作者单位： | 1. 第四军医大学唐都医院神经外科,西安,710038 2. 泸州医学院第一附属医院,646000 3. 三九脑科医院,广州,510510 4. 解放军458医院,广州,510602 5. 解放军463医院,沈阳,110042 6. 解放军海军总医院,北京,100037 7. 上海交通大学附属瑞金医院,200025 |
| 基金项目： | 国家十一五科技支撑计划课题(编号:2007BAI0703) |
| 摘 要： | 目的比较伏隔核损毁术与伏隔核加其他靶点联合损毁术治疗阿片类药物成瘾的长期疗效。方法从我国7个医疗中心接受过双侧伏隔核毁损术(单靶点)与双侧伏隔核加其他靶点联合毁损术(多靶点)治疗阿片类药物成瘾的两组病人中分别随机抽取75名病人,术后第5年回顾性随访研究,比较两组的复吸率和副反应发生率。结果单靶点组和多靶点组各有62例和60例病人接受并按计划完成随访。两组间复吸率和非特异性副反应的病人比例差异均无统计学意义(P=0.678,P=0.780)。多靶点组特异性副反应的比例与严重程度均高于单靶点组,差异有统计学意义(P=0.011,P=0.008)。结论与立体定向伏隔核单靶点损毁术相比,伏隔核加其他靶点联合损毁术治疗阿片类药物成瘾的复吸率未降低,但特异性副反应发生率明显增高。 |
| 关 键 词： | 阿片相关性障碍 立体定位技术 伏隔核 毁损术 |
Long-term therapeutic effect of combined lesioning of single-target and multi-target for opiate addiction |
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| Chang Chongwang,Wang Xuelian,Ge Shunnan,Wu Heming,Zhao Haikang,Chang Xiaozan,Wang Peng,Fang Wei,Li Min,Li Dingjun,Ming Yang,Wang Chongqi,Zeng Yanping,Wang Lugang,Cai Meiling,Yin Zhongmin,Wu Jing,Lu Wangsheng,Sun Yanjie,Han Ling,Li Dianyou,Chen Meijun,Gao Guodong. Long-term therapeutic effect of combined lesioning of single-target and multi-target for opiate addiction[J]. Chinese Journal of Minimally Invasive Neurosurgery, 2011, 16(2): 51-55 | |
| Authors: | Chang Chongwang Wang Xuelian Ge Shunnan Wu Heming Zhao Haikang Chang Xiaozan Wang Peng Fang Wei Li Min Li Dingjun Ming Yang Wang Chongqi Zeng Yanping Wang Lugang Cai Meiling Yin Zhongmin Wu Jing Lu Wangsheng Sun Yanjie Han Ling Li Dianyou Chen Meijun Gao Guodong |
| Affiliation: | Chang Chongwang1,Wang Xuelian1,Ge Shunnan1,Wu Heming1,Zhao Haikang1,Chang Xiaozan1,Wang Peng1,Fang Wei1,Li Min1,Li Dingjun2,Ming Yang2,Wang Chongqi3,Zeng Yanping3,Wang Lugang4,Cai Meiling4,Yin Zhongmin5,Wu Jing5,Lu Wangsheng6,Sun Yanjie6,Han Ling6,Li Dianyou7,Chen Meijun7,Gao Guodong1 1.Department of Neurosurgery,Tangdu Hospital,Fourth Military University of PLA,Xi'an,Shaanxi 710038,China,2.First Affiliated Hospital of Luzhou Medical College,Luzhou,Sichuan 646000,3.Sanjiu Brain Hospital,Guangzhou,Gua... |
| Abstract: | Objective To compare the long-term therapeutic effects of stereotactic lesioning of the nucleus accumbens and lesioning of the nucleus accumbens combined with others targets for opiate addiction.Methods Seventy-five patients were selected randomly and equally from patients with opiate addiction of two groups who underwent stereotactic lesioning of the bilateral nucleus accumbens(single-target group) and lesioning of the bilateral nucleus accumbens combined with others targets(multi-target group) respectivel... |
| Keywords: | opioid-related disorders stereotaxic techniques nucleus accumbens lesioning |
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