Effect of muscimol,a central GABA receptor agonist,on the catalepsy,striatal homovanillic acid increase,and analgesia induced by pilocarpine in rats |
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| Authors: | S. R. Naik M. R. Kelkar S. R. Amladi U. K. Sheth |
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| Affiliation: | (1) Laboratorio de Tecnologia Farmaceutica (LTF), Universidade Federal da Paraiba (UFPB), Joao Pessoa, PB, Brasil;(2) Pharmacology Research Unit, Council of Scientific and Industrial Research, Department of Pharmacology, Seth G.S. Medical College, 400 012 Bombay, India;(3) Iopiwalla National Medical College, 400 008 Bombay, India;(4) K.E.M. Hospital, 400 012 Bombay, India |
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| Abstract: | ![]()
Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation of pilocarpine-induced analgesia by muscimol is unrelated to an interaction of the GABAergic system with the striatal cholinergic or dopaminergic systems. |
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| Keywords: | Muscimol Catalepsy Analgesia Striatal homovanillic acid Pilocarpine |
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