口腔扁平苔藓患者心理因素与唾液脱氢表雄酮水平的关联性分析

目的: 分析口腔扁平苔藓(OLP)患者的焦虑、抑郁心理量表评分与唾液脱氢表雄酮(DHEA)水平的关系,阐明二者之间的关联性。 方法: 对71例OLP患者 [其中充血糜烂型OLP(EOLP)患者31例,非EOLP患者40例]和31例对照组受试者采用汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评定,并在早晨采集唾液,采用放射免疫法测定唾液DHEA水平,分析各组受试者焦虑、抑郁心理量表评分与唾液DHEA水平的相关性。 结果: EOLP组患者的HAMA评分和HAMD评分均明显高于对照组和非EOLP组(P<0.01),唾液DHEA浓度虽低于正常对照组,但差异无统计学意义 (P=0.054);非EOLP组患者的HAMA评分、 HAMD评分和唾液DHEA水平与对照组比较差异均无统计学意义(P>0.05)。EOLP组患者唾液DHEA水平与HAMA评分和HAMD评分呈负相关关系(r=-0.948,r=-0.966),非EOLP组患者的唾液DHEA水平与HAMA评分和HAMD评分亦呈负相关关系(r=-0.962,r=-0.971)。 结论: EOLP的发生、发展与患者的焦虑、抑郁等情绪障碍有关,其作用机制可能与患者唾液DHEA水平的降低有关。

Analysis on association between psychological factors and salivary DHEA level in patients with oral lichen planus

Objective: To explore the relationship between the scores of anxiety,depression and the salivary levels of dehydydroepiandrosterone(DHEA)in the patients with oral lichen planus (OLP),and to clarify the correlation between them. Methods: Thirty-one patients with erosive oral lichen planus (EOLP),40 patients with non-EOLP and 31 controls were investigated by the instruments Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD),respectively.The saliva of objects in various groups was collected in the morning for the determination of DHEA levels by radioimmunoassay to explore the relationship between the scores of anxiety,depression and the salivary levels of DHEA in various groups. Results: The scores of HAMA and HAMD of the patients in EOLP group were significantly higher than those in control group and non-EOLP group(P<0.01).The level of salivary DHEA of the patients in EOLP group was lower than that in control group,but there was no significant difference between two groups(P>0.05). There were no significant differences of the scores of HAMA HAMD and the levels of salivary DHEA of the objects between non-EOLP group and control group (P>0.05).The level of salivary DHEA of the patients in EOLP group was negatively correlated with their scores of HAMA(r=-0.948)and HAMD(r=-0.966 ).The level of salivary DHEA of the patients in non-EOLP group was also negatively correlated with their scores of HAMA(r=-0.962)and HAMD(r=-0.971).Conclusion: The occurrence and development of EOLP is related to anxiety and depression,and its mechanism may be related to the decrease of salivary DHEA level in the patients with EOLP.