阿托伐他汀钙治疗急性脑梗死的疗效及对血清 IL-6水平的影响

目的：观察阿托伐他汀钙治疗急性脑梗死的临床疗效及对血清白细胞介素-6(IL-6)水平的影响。方法将三台县人民医院100例发病72 h 内收治的急性脑梗死患者随机分为治疗组和对照组各50例。两组均给予常规治疗，治疗组在此基础上加用阿托伐他汀钙10 mg/d 口服，连用14 d。于治疗前、治疗后14 d 检测两组患者血清 IL-6水平，并比较两组神经功能缺损评分。结果两组治疗14 d 后神经功能缺损评分较治疗前明显改善，且治疗组改善程度较对照组更明显，差异有统计学意义(P <0.05)。治疗组治疗后血清 IL-6水平较治疗前明显降低(P <0.05)，且低于对照组，差异有统计学意义(P <0.05)。对照组治疗后血清 IL-6降低不明显(P >0.05)。结论阿托伐他汀钙能降低急性脑梗死患者的 IL-6水平，从而改善其神经功能。

Efficacy of Atorvastatin Calcium in Treatment of Patients with Cerebral Infarction and its influence on Serum interleukin-6

Objective To observe the clinical effects of atorvastatin calcium in the treatment of patients with acute cerebral infarction and its influence on serum interleukin 6 (IL-6).Methods A total of 100 patients within 72h of the onset of acute cerebral infarction were randomly divided into treatment group(n=50)and control group (n=50).Both groups were given conventional treatment,and the treatment group were given additional atorvastatin calcium 10 mg/d orally for 14 days.Changes of serum IL-6 levels of the two groups before and after treatment were tested and neurological deficit scores were compared between the two groups.Results After 14 days of treatment, the neurological deficit scores were obviously improved in both groups,and the improvement in treatment group were more apparent than control group.The difference was statistically significant (P <0.05).After treatment,the serum IL-6 levels of treatment group were significantly lower than those before treatment (P < 0.05 ),and were lower than those of control group,the difference of which was statistically significant(P < 0.05 ).There was no apparent decrease in the serum IL-6 levels in control group (P > 0.05 ).Conclusion Atorvastatin calcium can improve the neurological function of patients with acute cerebral infarction through reducing the serum IL-6 levels.