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| 复方丹参注射液对心肌缺氧的保护性观察 | |
| 引用本文： | 王亚利,张式暖,刘克花,魏志新,姜红心. 复方丹参注射液对心肌缺氧的保护性观察[J]. 潍坊医学院学报, 2000, 22(1): 43-44 |
| 作者姓名： | 王亚利 张式暖 刘克花 魏志新 姜红心 |
| 作者单位： | 1. 潍坊医学院附院,潍坊,261031 2. 潍坊医学病理学教研室,潍坊,261031 3. 潍坊医学院附属潍坊市人民医院 |
| 基金项目： | 山东省潍坊市科委课题(批准号96041) |
| 摘 要： | 目的 探讨复方丹参注射液对心肌的保护作用。方法 建立小鼠缺氧后心肌损伤模型,设治疗组和对照组共２５只小鼠,随机分为３组,实验２周后,取新鲜心肌标本,测琥珀酸脱氢酶（ＳＤＨ）,三磷酸腺苷酶（ＡＴＰ）,乳酸脱氢酶（ＬＤＨ）;光镜、电镜观察心肌病理性变化。结果 缺氧组ＳＤＨ,ＡＴＰ酶减少,ＬＤＨ升高,心肌间质水肿,心肌细胞线粒体肿胀、肌丝排列紊乱。复方丹参组、 心肌酶和心肌超微结构与对照组相比差异均无显 |
| 关 键 词： | 心肌 心肌缺氧 复方丹参注射液 治疗 |
| 修稿时间： | 1998-10-21 |
Protective Effect of Danshen to the Myocardium with Anoxia |
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| Wang Yali,ZhangShinuan,Liu Kehua. Protective Effect of Danshen to the Myocardium with Anoxia[J]. Journal of Weifang Medical College, 2000, 22(1): 43-44 | |
| Authors: | Wang Yali ZhangShinuan Liu Kehua |
| Abstract: | Objective To investigate Danshen prenvent the myocardium.Method 25 mice were divided into three groups,the control,the hypoxia and Danshen treated group.At two weeks after treament,sections of myocardium were made,succinic dehyrogenase (SDH),adenosine trphosphatase (ATP) and lactic dehydrogenase (LDH) were stined.Pathologic changes of myocardium were observed under light microscope and electric microscope.Result In hypoxia group,SDH and ATP decreased,while LDH increased.Mesenchyma of myocardium was edematous.Mitochondrions of myocardial cells enlarged,arrangement of filaments was irregular.There was not a significant difference between Danshen treated and control group.Conclusion Anoxia causes enzymohistochemical and morphological changes of myocardium.Danshen may prevent the myocardium from damage with anoxia. [ |
| Keywords: | Myocardium Danshen Anoxia |
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