Enhancement of genomic instability by 17{beta}estradiol in minisatellite sequences of X-ray-transformed mouse 10T1/2 cells |
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| Authors: | Paquette Benoit |
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| Affiliation: | Department of Nuclear Medicine and Radiobiology,Faculty of Medicine,Universite de Sherbrooke 3001 12th Avenue North,Sherbrooke,Quebec,JIH 5NA Canada |
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| Abstract: | ![]()
The female hormone 17ß-estradiol is involved in thedevelopment of breast cancer, an effect usually attributed toits capacity to stimulate the replication of preneoplastic andmalignant cells. In this study, we report that 17ß-estradiolenhances the onset of genomic rearrangements, a type of genomicinstability, in minisatellite sequences of malignant 10T1 |
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