| 脂质体携载前列腺素E1对止血带休克大鼠脂质过氧化的影响 |
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| 引用本文： | 张连元 刘秀华. 脂质体携载前列腺素E1对止血带休克大鼠脂质过氧化的影响[J]. 中国病理生理杂志, 1997, 13(6): 651-654 |
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| 作者姓名： | 张连元 刘秀华 |
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| 作者单位： | [1]华北煤炭医学院病理生理教研室 [2]北京医科大学心血管基础研究所 |
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| 摘 要： | 在大鼠止血带休克模型上观察了应用脂质体携载前列腺素Ｅ１对止血带休克的影响，发现以脂质体包裹前列腺素Ｅ１可显著缓解应用止血带的动物松带后的血压进行性降低及血浆乳到脱氢酶，组织蛋白酶Ｄ活性的增高，与此同时降低了血浆和组织中脂过氧化产物丙二醛的含量，但应用游离前列腺素Ｅ１则无上述明显效果。表明，脂质体携带前列腺素Ｅ１具有减轻大鼠松解止血带后的细胞损伤作用，这一作用可能是通过抗组织脂质过氧化反应实现的。
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| 关 键 词： | 脂质体 前列腺素E 休克 脂质过氧化 |
Effect of liposome - carried prostaglandin E1 on lipid peroxide in tourniquet shock rats |
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| Zhang Lian - Yuan, Zhang Zhi - Wei, Dong Shu - Yun, Zheng Su- Qin, Liu Xiu - Hua Zhang Ling - Zhi,Tang Chao - Shu, Su Jing - Yi. Effect of liposome - carried prostaglandin E1 on lipid peroxide in tourniquet shock rats[J]. Chinese Journal of Pathophysiology, 1997, 13(6): 651-654 |
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| Authors: | Zhang Lian - Yuan Zhang Zhi - Wei Dong Shu - Yun Zheng Su- Qin Liu Xiu - Hua Zhang Ling - Zhi Tang Chao - Shu Su Jing - Yi |
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| Abstract: | The experiment was Performed on the model of rat tourniquet shock(TS). It was found that beatment with liposome - carried prostaglandin E1 (PGE1 )significantly alleviated hypotension, lowered activities of plasma lartate dehydrogenase and cathepsin D, decreased malondialdehyde (MDA) content which is the metabolite of lipid peroxide in the plasma and tissue after releasing tourniquet. The free PGE1 dids' t have action as mentioned above . The resultS suggested that liposome -carried PGE1 could alleviate cell damage by resisting lipid peroxidation after releasing tourniquet. |
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| Keywords: | Liposomes Prostaglandins E Shock |
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