2型糖尿病肾病患者糖化血红蛋白与尿酸检测的意义

目的探讨2型糖尿病患者糖化血红蛋白与尿酸检测的临床意义。方法选取40例2型糖尿病肾病患者作为研究1组,40例未发生肾病的糖尿病患者作为研究2组,随机选取40例健康人作为对照组,分别测定各组空腹血糖、糖尿化血红蛋白（HbA1c）、尿酸（UA）2、4 h尿微量白蛋白排泄率（UAER）和血肌酐,比较各组上述指标的情况。结果研究1组、研究2组HbA1c、UA均高于对照组;研究1组HbA1c、UA水平均高于研究2组,差异有统计学意义（P〈0.05）。研究1组中肾功能失代偿者HbA1c、UA水平高于肾功能代偿者,差异有统计学意义（P〈0.05）。结论 2型糖尿病肾功能损害程度与患者体内糖化血红蛋白、血尿酸水平呈显著相关,糖化血红蛋白与尿酸检测对于2型糖尿病肾病具有重要意义。

Significance of Detecting Serum Levels of Glycosylated Hemoglobin and Uric Acid in Type 2 Diabetic Nephropathy

Objective To explore the clinical value of detecting the serum levels of glycosylated hemoglobin and uric acid in patients with type 2 diabetic nephropathy. Methods Forty patients with diabetes nephrosis were served as research group 1,40 patients with diabetic served as research group 2,and 40 healthy individuals were selected as control group.Fasting blood glucose,HbA1c,UA,24 h UAER and Cr of the three groups were determined,and the results were compared among them. Results The levels of HbA1c and UA in research groups 1 and 2 were higher than those of control group.The levels of HbA1c and UA in research group 1 were higher than those in research group 2,and the difference was statistically significant(P<0.05).The levels of HbA1c and UA in the renal decompensation patients of research group 1 were higher than those of patients with compensatory stage of renal function in research group 1,and the difference was statistically significant(P<0.05). Conclusions The extent of renal impairment is positively correlated with the levels of HbA1c and UA in patients with type 2 diabetic nephropathy.Detection of HbA1c and UA has an important significance in patients with type 2 diabetic nephropathy.