| 正交试验法优选苦参配方颗粒的提取工艺 |
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| 引用本文： | 何健,韩正洲,张跃飞. 正交试验法优选苦参配方颗粒的提取工艺[J]. 海峡药学, 2011, 23(5): 25-26 |
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| 作者姓名： | 何健 韩正洲 张跃飞 |
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| 作者单位： | 华润三九医药股份有限公司,深圳,518029 |
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| 基金项目： | 国家"十五"重大科技专项"创新药物和中药现代化"第三批科题;课题 |
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| 摘 要： | 目的优选苦参配方颗粒的提取工艺。方法采用L9（34）正交试验,研究浸泡时间、提取时间、加水量、提取次数对苦参提取工艺的影响,以苦参碱提取率作为主要考察指标,优选提取工艺。结果苦参配方颗粒的优选提取工艺为加10倍量水,浸泡30min,煎煮二次,每次提取1h。结论该提取工艺能够有效地提取苦参碱,且适用于大生产,可作为苦参配方颗粒的提取工艺。
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| 关 键 词： | 苦参配方颗粒 提取工艺 正交试验 |
Optimization of the Extraction process of Sophora flavescens Dispensing Granules by orthogonal test |
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| HE Jian,HAN Zhen-zhou,ZHANG Yue-fei. Optimization of the Extraction process of Sophora flavescens Dispensing Granules by orthogonal test[J]. Strait Pharmaceutical Journal, 2011, 23(5): 25-26 |
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| Authors: | HE Jian HAN Zhen-zhou ZHANG Yue-fei |
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| Affiliation: | (China Resources Sanjiu Medical and Pharmaceutical Co.,LTD,Shenzhen 518029,China) |
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| Abstract: | OBJECTIVE To optimize the extraction process of Sophora flavescens dispensing Granules.METHODS Researched the influences of soak time,extracting time,water volume and extracting times on extraction techniques for Lighiyellow Sophora Root,with the matrine in extracts as index,the optimal condition by L9（34）orthogonal test was studied.RESULTS The optimum extraction process conditions were determined as follows：To add water with 1∶10,soak time 30 minutes,and to decoct 2 times,decoct time 1 hours every time.CONCLUSION The extraction process is reasonable;The method can be used for industrial production. |
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| Keywords: | Sophora flavescens Dispensing Granules Extraction process Orthogonal test |
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