慢性主观性耳鸣患者大脑局部一致性和灰质结构的MRI分析

目的 采用MRI观察慢性主观性耳鸣患者大脑局部神经活动和灰质结构的改变特点。方法 对21例慢性主观性耳鸣患者（病例组）和21名健康志愿者（对照组）行结构与功能MR扫描，采用基于体素的形态学及局部一致性（ReHo）方法，分析大脑灰质结构和体积改变。结果 与对照组比较，病例组右颞上回、颞中回和颞下回ReHo值增高（P<0.05），右眶部额中回和三角部额下回、左侧额中回和角回及小脑蚓部ReHo值降低（P<0.05），右颞中回和双侧额上回灰质体积缩小（P<0.01）。病例组右侧颞中回ReHo值与耳鸣残疾量表评分呈正相关（r=0.604，P=0.005）。结论 主观性耳鸣患者在听觉和非听觉不同脑区存在脑功能活动和灰质体积的改变，为寻找神经影像学标记提供了参考基础。

MRI analysis of regional homogeneity and gray matter structure in chronic subjective tinnitus

Objective To observe changes of brain function synchronized activity and gray matter structure alterations in patients with chronic subjective tinnitus (ST) with MRI.Methods Resting-state fMRI and 3D T1WI were obtained in 21 chronic ST patients (case group) and 21 healthy volunteers (control group). The voxel-based morphometry and regional homogeneity (ReHo) were used to analyze changes of the gray matter structure and volume.Results Compared with control group, ReHo values of the right superior, middle and inferior temporal gyrus increased in case group (P<0.05), ReHo values of the right middle orbital frontal gyrus/inferior triangle frontal gyrus, left middle frontal gyrus/angular gyrus and cerebellar vermis decreased (P<0.05), and the gray matter volume of the right middle temporal gyrus, superior dorsolateral frontal gyrus and left superior medial frontal gyrus decreased in case group (P<0.01). Furthermore, ReHo values of the right middle temporal gyrus were positively correlated with tinnitus handicap inventory scores (r=0.604, P=0.005) in case group.Conclusion The neural function synchronized activity and gray matter volume changes in the auditory and non-auditory brain regions of patients with chronic ST, providing references for finding possible neuroimaging markers.