福建省龙岩市农村居民碘营养水平与甲状腺功能调查

目的了解龙岩市农村居民碘营养水平和甲状腺功能,为防治提供依据。方法用B超法检测儿童甲状腺,用砷铈催化分光光度法检测尿碘和饮用水碘含量,直接滴定法检测盐碘含量,直接化学发光免疫分析法检测甲状腺功能指标[总、游离三碘甲腺原氨酸（TT3、FT3）,总、游离甲状腺素（TT4、FT4）]、促甲状腺激素（TSH）、甲状腺球蛋白（Tg）、甲状腺球蛋白抗体（TGA）、抗甲状腺过氧化物酶抗体（TPOAb）。结果居民饮用水碘含量0~2.7μg/L,;8~10岁儿童甲状腺肿大率为1.6%（2/129）;居民户碘盐覆盖率、合格碘盐食用率均为100%（85/85）;儿童、成人、孕妇和哺乳期妇女尿碘中位数分别为343.6、353.1、178.5和174.4μg/L;儿童、成人存在碘摄入过量;孕妇、哺乳期妇女尿碘处于适宜水平;儿童TT3、FT3、TT4、FT4,成人FT3、TT4、FT4,孕妇TT3、FT3、TT4异常比例都超过10%,这4类人群TGA、TPOAb高于正常的比率分别为1.9%（5/265）、7.9%（24/305）。结论龙岩市部分农村地区儿童、成人碘摄入过量,食用盐碘浓度有下调空间;建议将甲状腺功能监测列入常规监测内容。

Investigation on iodine nutrition and thyroid function in rural residents of Longyan,Fujian China

Objective To investigate the iodine nutrition and thyroid function in rural residents of Longyan city for IDD control and prevention.Methods The goiter of children was detected by B ultrasound,urinary and water iodine content was determined by arsenic cerium catalytic spectrophotometric assay.Iodine content was determined by direct titrimetric.Thyroid function（TT3,TT4,FT3,FT4）and TSH,Tg,TGA and TPOAb were measured by direct chemiluminescence immunoassay.Results The iodine content of drinking water was 0-2.7μg/L.The goiter rate aged 8to 10was 1.6%（2/129）.Both household iodized salt coverage and qualified iodized salt rates were 100%（85/85）.The medians of urinary iodine of children,adults,pregnant and lactating women were 343.6,353.1,178.5and 174.4μg/L respectively.The children and adult existed excessive iodine intake.The urinary iodine of pregnant and lactating women were at suitable level.The abnormal rates of TT3,FT3,TT4,FT4for children,FT3,TT4and FT4for adult and TT3,FT3,TT4for pregnant women were over 10%.The rates of TGA,TPOAb of four groups for higher than normal were 1.9%（5/265）and 7.9%（24/305）respectively.Conclusion The iodine intake of children and adult in rural areas is excessive in Longyan.Edible salt iodine concentration reasonable reducing may be considered.The determine of thyroid function should be recommended in routine surveillance.