焦虑性与非焦虑性抑郁临床特征及疗效对照研究

目的 探讨焦虑性与非焦虑性抑郁患者的临床特征及疗效,为临床识别和有效治疗焦虑性抑郁提供依据.方法 对195例在我院住院的抑郁症患者,采用汉密顿抑郁量表(焦虑/躯体化因子分≥7分定义为焦虑性抑郁)筛选出焦虑性抑郁患者,统计焦虑性与非焦虑性抑郁患者的人口学资料及其临床特征;采用"两步"治疗法对两组患者进行药物治疗,观察12周.于治疗3周、6周、9周、12周末采用汉密顿抑郁量表、副反应量表评估临床疗效及不良反应.结果 195例抑郁症患者中,焦虑性抑郁92例,发生率为47.18%.与非焦虑组患者相比,焦虑性抑郁患者文化程度较低、无职业者多、年龄偏大、总病期较长、本次抑郁发作时间较长、抑郁发作次数较多、抑郁症状更严重、药物治疗痊愈率较低、达痊愈的治疗时间较长,差异均有显著或极显著性(P＜0.05或0.01).结论 焦虑性抑郁在抑郁症中常见,常规治疗方案疗效不理想,在临床治疗过程中需要对其焦虑性抑郁状况进行评估,制定有针对性的治疗方案,以提高临床疗效、有效地防止疾病的慢性化. 顿抑郁量表、副反应量表评估临床疗效及不良反应.结果 195例抑郁症患者中,焦虑性抑郁92例,发生率为47.18%.与非焦虑组患者相比,焦虑性抑郁患者 化程度较低、无职业者多、年龄偏大、总病期较长、本次抑郁发作时间较长、抑郁发作次数较多、抑郁症状更严重、药物治疗痊愈率较低、达痊愈的治疗时间较长,差异均有显著或极显著性(P＜0.05或0.01).结论焦虑性抑郁在抑郁症中常见,常规治疗方案疗效不理想,在临床治疗过程中需要对其焦虑性抑郁状况进行评估,制定有针对性的治疗方案,以提高临床疗效、有效地防止疾病的慢性化. 顿抑郁量表、副反应量表评估临床疗效及不良反应.结果 195例抑郁症患者中,焦虑性抑郁92例,发生率为47.18%.与非焦虑组患者相比,焦虑性抑郁患者 化程度较低、无职业者多、年龄偏大、总病期较长、本次抑郁发作时间较长、抑郁发作次数较多、抑郁

Clinical features and curative effect in anxious versus nonanxious depression

Objective To explore the clinical features and curative effect in anxious versus nonanxious depression in order to provide basis for clinical identification and treating anxious depression effectively. Methods Anxious depression patients were screened from 195 depression ones hospitalized in our hospital with the Hamilton Depression Scale （HAMD, patients with anxiety/somatization score ≥ 7 defined as anxious depression）, and demographic data and clinical features added up for anxious and nonanxious depression patients; the ＂two-step＂ medication was conducted for both groups for 12 weeks. Clinical effieacies were assessed with the HAMD and adverse reactions with the Treatment Emergent Symptom Scale （TESS） at the end of the 3rd, 6th, 9th and 12th week. Results Of the 195 depression patients, 92 （47.18%）were anxious depression. Copmpared with nonanxious depression patients, anxious depression ones had such clinical features as lower educational level, more being jobless, older, longer whole disease period, longer depressive episode time of this time, more frequency of depressive episode, more grave depressive symptoms, lower cure rate of medication, longer time of therapy, differences were significant or very significant（P〈0.05 or 0.01）. Conclusion Anxious depression is common in depressive patients and conventional therapy non-ideal, their anxious depression status needs to be clinically evaluated and treatment regimen should be purposeful in order to improve clinical efficacy and prevent chronicity of the disease effectively.