| 狼疮性肾炎患者尿血栓素—前列环素平衡变化及其临床意义 |
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| 引用本文： | 袁伟杰 乔德彪. 狼疮性肾炎患者尿血栓素—前列环素平衡变化及其临床意义[J]. 第二军医大学学报, 1993, 14(5): 444-447 |
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| 作者姓名： | 袁伟杰 乔德彪 |
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| 作者单位： | 长海医院肾内科 200433(袁伟杰，崔若兰，张家庆，钟铁)，长海医院内分泌科 200433(乔德彪) |
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| 摘 要： | 作者观察了２４例狼疮性肾炎患者、１２例正常对照者尿ＴｘＡ２、ＰＧＩ２代谢产物ＴＸＢ２、６－ｋｅｔｏ－ＰＧＦ１α含量。结果表明，与正常组相比较，各组狼疮性肾炎患者尿ＴＸＢ２含量均增高６－ｋｅｔｏ－ＰＧＦ１α比值与尿蛋白量呈正相关（ｒ＝０．７４）。表明狼疮性肾炎患者肾组织内存在严重的ＴＸＡ２－ＰＧＩ２平衡失调，前列腺素代谢异常可能与狼疮性肾炎的发生、发展有关。检测尿ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比
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| 关 键 词： | 狼疮性肾炎 血栓素B2 前列腺素 |
Changes of Urine Thromboxane A_2-Prostacyclin Balance in Patients with Lupus Nephritis and Their Clinical Significance |
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| Yuan Weijie,Cui Ruolan,Zhang Jiaqing,Zhong Tie. Changes of Urine Thromboxane A_2-Prostacyclin Balance in Patients with Lupus Nephritis and Their Clinical Significance[J]. Former Academic Journal of Second Military Medical University, 1993, 14(5): 444-447 |
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| Authors: | Yuan Weijie Cui Ruolan Zhang Jiaqing Zhong Tie |
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| Abstract: | The levels of urine thromboxane B, (TXB2) and 6-keto-PGF1a were measured by radioimmunoassay in 24 patients with lupus nephritis and 12 normal subjects. The results showed that the level of TXB2 and the ratio of TXB2/6- keto- PGF1x in urine were significantly higher, while the level of urine 6-keto-PGF1x( was lower in patients with lupus nephritis than that in normal group. The ratio of TXB2/6-keto-PGF1a in urine was correlated positively to the content of urine protein. These results indicate that there is TXA2-PGI2 imbalance in the kidney in patients with lupus nephritis. TXA2 can play an important pathogenetic role in the progression of lupus nephritis in patients. The ratio of TXB2/6-keto-PGF1x in urine may serve as a parameter in evaluating patients with lupus nephritis. |
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