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实验性小鼠柯萨奇B3病毒心肌炎自然杀伤细胞活性和干扰素测定
引用本文:沈茜 汪美先. 实验性小鼠柯萨奇B3病毒心肌炎自然杀伤细胞活性和干扰素测定[J]. 第二军医大学学报, 1993, 14(4): 344-347
作者姓名:沈茜 汪美先
作者单位:长海医院临床实验诊断科,第四军医大学分子病毒研究室,长海医院心血管内科 200433,西安 710032,200433
摘    要:


关 键 词:柯萨奇病毒B 心肌炎 杀伤细胞

The Measurement of NK Cells Activity and Interferon Titers in Murine Coxsackievirus B_3 Induced Myocarditis
Shen Qian,Wang Meixian,Zhang Tonghua. The Measurement of NK Cells Activity and Interferon Titers in Murine Coxsackievirus B_3 Induced Myocarditis[J]. Former Academic Journal of Second Military Medical University, 1993, 14(4): 344-347
Authors:Shen Qian  Wang Meixian  Zhang Tonghua
Abstract:
The level of interferon (IFN) in serum and homogenized cardiac tissue, and the activity of natural killer cells in Coxsackievirus B3 induced myocarditis in BALB/c mice were determined. NK cell cytolytic activity and IFN titers peaked on day 3~ 7 postinoculation (p.i.) and then declined. Virus titers in heart tissue reached a maximum on day 7 p.i. and then declined. These results suggest that the increase of NK cell activity and IFN titers provides some protection against Cox B, induced myocarditis by limiting virus replication in heart tissue.
Keywords:Coxsackie B viruses  myocarditis  interferon  killer cell   natural  animal  mice
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