| 阿立哌唑的合成 |
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| 引用本文： | 朱航昌,陈国华,张军忍,李强.阿立哌唑的合成[J].中国药物化学杂志,2006,16(2):108-109. |
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| 作者姓名： | 朱航昌 陈国华 张军忍 李强 |
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| 作者单位： | 中国药科大学,药物化学教研室,江苏,南京,210009 |
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| 摘 要： | 以间氨基苯甲醚为原料,经缩合、傅克酰化、成醚、取代4步制得抗精神病药阿立哌唑,并对原工艺进行改进。目标物的化学结构经红外光谱、核磁共振氢谱及质谱确证,该合成方法原料易得,操作简便,总收率为45·1%。
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| 关 键 词： | 药物化学 药物制备 工艺改进 阿立哌唑 |
| 文章编号： | 1005-0108（2006）02-0108-02 |
| 收稿时间： | 2005-09-19 |
| 修稿时间： | 2005年9月19日 |
Synthesis of aripiprazole |
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| ZHU Hang-chang,CHEN Guo-hua,ZHANG Jun-ren,LI-Qiang.Synthesis of aripiprazole[J].Chinese Journal of Medicinal Chemistry,2006,16(2):108-109. |
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| Authors: | ZHU Hang-chang CHEN Guo-hua ZHANG Jun-ren LI-Qiang |
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| Institution: | Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 21009, China |
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| Abstract: | Aripiprazole was synthesized by condensation of 7 -( 4-bromobutoxy)-3,4-dihydrocarbostyril(5) and 1-(2,3-dichlor olphenyl)-piper azine dihydrochloride.Compound 5 was prepared by condensation of 7-hydroxy-3,4 -dihydrocarbostyril(4) and 1,4-dibromobutane.Compound 4 was obtained from m-a nisidine by condensation and F-C acylation.The structure of target com pound was confirmed by IR,~1H-NMR,MS and the total yield was 45.1% .This procedure has advantages of simple starting material and convenient operat ions. |
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| Keywords: | medicinal chemistry drug preparation process improv ement aripiprazole |
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