Influence of chemically modified tetracyclines on proliferation, invasion and migration properties of MDA-MB-468 human breast cancer cells |
| |
Authors: | Qinghui Meng Jingwen Xu Itzhak D. Goldberg Eliot M. Rosen Robert A. Greenwald Saijun Fan |
| |
Affiliation: | (1) Department of Radiation Oncology, Laboratory of Molecular Oncology, USA;(2) Division of Rheumatology. Department of Medicine, Long Island Jewish Medical Center, (The Long Island Campus for the Albert Einstein College of Medicine), New Hyde Park, NY 11040, USA |
| |
Abstract: | Chemically modified tetracyclines (CMTs) are promising anti-cancer agents. In this study, we found that CMT-3 and CMT-8 showed dose-dependent cytotoxicities in MDA-MB-468 human breast cancer cells. Moreover, both CMT-3 and CMT-8 significantly inhibited in vitro cell migration and invasion at non-cytotoxic concentrations. Anti-invasion and migration potentials of the CMTs were associated with an increased expression of E-cadherin/catenins (α, β and γ-catenin) and tumor suppressor BRCA1. In addition, CMT-3 and CMT-8 abolished or reduced spontaneous and HGF/SF-induced cell invasion and migration in U-373 MG human glioblastoma cells. Our current finding is the first demonstration that CMT-3 and CMT-8 can activate the function of invasion suppressor molecules associated with the suppression of breast cancer cell invasion and migration. Thus, clinical application of CMTs may provide potential benefit for suppression of breast cancer growth, invasion and metastasis. This revised version was published online in July 2006 with corrections to the Cover Date. |
| |
Keywords: | BRCA1 breast cancer chemically modified tetracycline E-cadherin/catenin invasion migration |
本文献已被 PubMed SpringerLink 等数据库收录! |
|