| 表皮干细胞的生物学特性及应用 |
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| 引用本文： | 赖麒,熊爱兵.表皮干细胞的生物学特性及应用[J].中国组织工程研究与临床康复,2011,15(36). |
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| 作者姓名： | 赖麒 熊爱兵 |
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| 作者单位： | 泸州医学院附属医院整形烧伤科,四川省泸州市 ,646000 |
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| 摘 要： | 背景:尽早去除创面坏死组织、重建皮肤结构和功能,是大面积深度烧伤治疗的关键和最终目标.表皮干细胞作为皮肤组织特异性干细胞,拥有无可置疑的潜能.目的:总结表皮干细胞的生物学特性及应用现状.方法:应用计算机检索2000-01/2010-10 PubMed数据库相关文章,检索词"epidermal stem cells,basic study",并限定文章语言种类为English.同时计算机检索2005-01/2010-10万方数据库相关文章,检索词为"表皮干细胞",并限定文章语言种类为中文.共检索到文献271篇,最终纳入符合标准的文献38篇.结果与结论:表皮干细胞是具有多向分化潜能、自我更新能力和高度增殖能力的细胞,具有慢周期性和对基底膜的黏附能力,其增殖分化受到壁龛及Wnt信号通路、MAPK、c-Myc、Notch信号传导通路、细胞因子等的调控.目前尚无公认的特异性标志物,可用于创面修复、基因治疗、组织工程领域.随着表皮干细胞研究的深入,将为皮肤基础研究、创面功能修复和皮肤遗传病的治疗提供新途径.
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| 关 键 词： | 表皮干细胞 特性 增殖 应用 综述文献 |
Biological characteristics and application of epidermal stem cells |
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| Lai Qi,Xiong Ai-bing.Biological characteristics and application of epidermal stem cells[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(36). |
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| Authors: | Lai Qi Xiong Ai-bing |
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| Institution: | Lai Qi,Xiong Ai-bing Department of Plastic Burn,Affiliated Hospital of Luzhou Medical College,Luzhou 646000,Sichuan Province,China |
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| Abstract: | BACKGROUND:To remove the necrotic tissue of the wound surfaces as early as possible,and rebuild the structure and function of skin is the ultimate therapeutic target of extensive deep burn.Epidermal stem cell as a specific stem cell in skin tissue has its incontestable potentials.OBJECTIVE:To review the research status on biological characteristics and application of epidermal stem cells in recent years.METHODS:An online search of PubMed database was performed using key words of epidermal stem cells,basic s... |
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| 本文献已被 CNKI 万方数据 等数据库收录！ |
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