Comparison of the effects of 9-tetrahydrocannabinol, 11-hydroxy- 9-tetrahydrocannabinol, and ethanol on the electrophysiological activity of the giant axon of the squid |
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| Authors: | R O Brady E Carbone |
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| Affiliation: | Developmental and Metabolic Neurology Branch, National Institute of Neurological Diseases and Stroke USA;Laboratory of Neurobiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20014 USA |
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| Abstract: | ![]()
External and intra-axonal application of Δ9-tetrahydrocannabinol was without effect on impulse conduction in the giant axon of the squid whereas 10?8m 11-hydroxy-Δ9-tetrahydrocannabinol reversibly blocked conduction in this preparation. This pharmacological effect of 11-hydroxy-Δ9-tetrahydrocannabinol compares in some respects with that produced by the intra-axonal injection of ethanol into these fibres. |
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