重症大疱性药疹角质形成细胞凋亡的研究

重症多形红斑和中毒性表皮坏死松解症属于重症大疱性药疹,临床表现为广泛的表皮坏死剥脱,组织病理表现为广泛的角质形成细胞凋亡,表皮与真皮分离.研究认为,穿孔素/颗粒酶和Fas/FasL可能是参与诱导角质形成细胞凋亡的主要因素;提出可在支持疗法基础上联合应用多种抗凋亡药物.因此,文中对重症大疱性药疹的抗凋亡治疗进行综述.

Keratinocyte apoptosis in severe bullous drug eruptions

Both Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) belong to severe bullous drug eruptions. Both of them are clinically characterized by extensive epidermal necrosis and exfoliation, and histologically characterized by generalized apoptosis of keratinocytes, a process that results in the separation of epidermis from dermis. There is evidence that keratinocyte apoptosis is mainly ascribed to perforin/granzyme B and Fas/FasL. Besides supportive treatment, the application of multiple antiapoptotic agents could be of potential benefit to the management of severe bullous drug eruptions. This article presents the antiapoptotic therapy of severe bullous drug eruptions.