|
|||||
|
|
The role of acetylation in the mutagenicity of the antitumor agent, batracylin |
|
| Authors: | Stevens, Gregory J. LaVoie, Edmond J. McQueen, Charlene A. |
| Affiliation: | Department of Pharmacology and Toxicology, University of Arizona Tucson, AZ 85721 1Department of Pharmaceutical Chemistry, Rulgers, The State University of New Jersey Piscataway, NJ 08855, USA |
| Abstract: | The role of acetylation in the genotoxicity of the heterocyclicamine, batracylin, was evaluated in Salmonella typhimurium strainsexpressing various levels of N-and O-acetyltransferase activity.A significant correlation was observed between batracylin-inducedmutagenicity and bacterial N-acetyltransferase activity. Strainswith the greatest capacity for N-acetylating batracylin (YG1012 and YG 1024) were the most sensitive to the mutagenic effectsof the drug. The number of revertants/nmol batracylin and theformation of acetylbatracylin were |
| Keywords: | |
| 本文献已被 Oxford 等数据库收录！ | |