The HLA-G low expressor genotype is associated with protection against bipolar disorder |
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| Authors: | Monojit Debnath,Marc Busson,Sté phane Jamain,Bruno Etain,Nora Hamdani,José Oliveira,Wahid Boukouaci,Kahina Amokrane,Hé lè ne Moins-Teisserenc,Mohamed Lajnef,Djaouida Bengoufa,Alain Malafosse,Frank Bellivier,Chantal Henry,Jean-Pierre Kahn,Rajagopal Krishnamoorthy,Dominique Charron,Marion Leboyer,Ryad Tamouza |
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| Affiliation: | 1. INSERM, UMRS 940, Hôpital Saint Louis, Paris F75010, France;2. INSERM, U 955, IMRB, Psychiatrie Genetique, Créteil 94000, France;3. Laboratoire Jean Dausset, Hôpital Saint Louis, Paris F75010, France;4. Université Paris-Est-Créteil, Faculté de Medecine, Créteil 94000, France;5. AP-HP, Pôle de Psychiatrie, Groupe Hospitalier Henri Mondor, Créteil F-94000, France;6. Fondation FondaMental, Créteil, France;g Univ. Paris Diderot, Sorbonne Paris, Cité, France;h Département de Psychiatrie, Université de Genève, Genève, CH-1205 Suisse, Switzerland;i INSERM, U 763, Robert Debré Hospital, Paris, Paris F-7519, France;j Service de Psychiatrie et Psychologie Clinique, CHU de Nancy, Hôpitaux de Brabois, F-54500 Vandoeuvre Les Nancy, France |
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| Abstract: | ![]()
Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc = 0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc = 0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed. |
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| Keywords: | Bp, base pair BD, bipolar disorder CTLA4, cytotoxic T lymphocyte antigen 4 CI, confidence interval EBV, Epstein-Barr virus CMV, cytomegalovirus HSV, Herpes simplex virus HERV-W, human endogenous retrovirus-W HTLV-1, human T cell leukemia/lymphoma virus type 1 GWAS, genome-wide association studies miRNAs, microRNAs OR, odds ratio PCR, polymerase chain reaction Treg, regulatory T cells sHLA-G, Soluble HLA-G |
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