Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging |
| |
| Authors: | Madhav Thambisetty Lori L. Beason-Held Yang An Michael Kraut Jeffrey Metter Josephine Egan Luigi Ferrucci Richard O'Brien Susan M. Resnick |
| |
| Affiliation: | 1. Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA;2. Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA;3. Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;4. Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA;5. Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA;6. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA |
| |
| Abstract: | ![]()
We investigated whether individuals with impaired glucose tolerance (IGT) in midlife subsequently show regionally specific longitudinal changes in regional cerebral blood flow (rCBF) relative to those with normal glucose tolerance (NGT). Sixty-four cognitively normal participants in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging underwent serial 15O-water positron emission tomography scans (age at first scan, 69.6 ± 7.5 years) and oral glucose tolerance tests 12 years earlier (age at first oral glucose tolerance test, 57.2 ± 11.1 years). Using voxel-based analysis, we compared changes in rCBF over an 8-year period between 15 participants with IGT in midlife and 49 with NGT. Significant differences were observed in longitudinal change in rCBF between the IGT and NGT groups. The predominant pattern was greater rCBF decline in the IGT group in the frontal, parietal, and temporal cortices. Some brain regions in the frontal and temporal cortices also showed greater longitudinal increments in rCBF in the IGT group. Our findings suggest that IGT in midlife is associated with subsequent longitudinal changes in brain function during aging even in cognitively normal older individuals. |
| |
| Keywords: | Insulin resistance Impaired glucose tolerance Brain function PET Cerebral blood flow Alzheimer's Aging |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
