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Analysis of EIF4G1 in Parkinson's disease among Asians |
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| Authors: | Yi Zhao Patrick Ho Kumar-M. Prakash Jia-Nee Foo Jian-Jun Liu Wing-Lok Au Louis C. Tan Eng-King Tan |
| Affiliation: | 1. Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Singapore;2. Genome Institute of Singapore, Singapore;3. Department of Neurology, Tan Tock Seng Hospital, National Neuroscience Institute, Singapore;4. Duke-NUS Graduate Medical School, Singapore |
| Abstract: | Sequence analysis of all the exons of EIF4G1 in 96 Asian patients with Parkinson's disease (PD) did not reveal any pathogenic mutations. A novel coding variant (Pro693Ser) in exon 15 (position 2077) was detected in one PD patient but not in 539 control subjects. Analysis of a coding polymorphic variant (rs2178403) in 1330 subjects revealed similar frequency between control subjects (0.638) and PD patients (0.640). EIF4G1 is an uncommon cause of PD in our Asian cohort. |
| Keywords: | Parkinson's disease Gene |
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