特发性血小板减少性紫癜的克隆性研究

特发性血小板减少性紫癜(ITP)患者的血小板糖蛋白上存在自身抗原表位，这些抗原表位定位于糖蛋白的某些特定区域，其数量有限。在部分慢性ITP患者中，存在B淋巴细胞和(或)T淋巴细胞的克隆性扩增，其自身抗体是克隆性起源的。这些研究对于探索特异性高、毒性小的靶向性治疗和揭示其发病机制具有重要意义。本综述讨论了ITP自身抗体的克隆限制性和B淋巴细胞的克隆性扩增，ITP中T淋巴细胞的克隆性和研究ITP克隆性的意义。

Study on the Clonal Characteristics of Idiopathic Thrombocytopenic Purpura--Review

The autoantigenic epitopes carried by the platelet glycoprotein in patients with idiopathic thrombocytopenic purpura (ITP) have been observed to localize on the specific regions of glycoprtein. There is a limited number of autoantigenic epitopes on the respective glycoproteins. The clonal B-cell and /or T cell expansion have been detected in some patients with ITP,and the autoantibodies is clonally derived. These researchs are of clinical importance since identification of clonally derived autoantibodies not only may help to discover the pathogenesis of ITP but also lead to less toxic and more specific therapies. In this review,the clonal limition of autoantibody and clonal expassion of B-lymphocyte is ITP,clonal characteristics of T-lymphocyte in ITP,and significance of research on clones in ITP were discussed and summrized.