Calcium channel blockers in affective illness: role of sodium-calcium exchange |
| |
| Authors: | R S el-Mallakh W A Jaziri |
| |
| Affiliation: | Department of Psychiatry, University of Connecticut Health Center, Farmington. |
| |
| Abstract: | ![]()
Available evidence suggests that verapamil and perhaps other calcium channel blockers are effective in treating mania but not unipolar depression. This article briefly reviews the clinical experience and reexamines potential mechanisms. It is proposed that antimanic efficacy is primarily related to inhibition of sodium-calcium counterexchange rather than calcium channel blockade. |
| |
| Keywords: | |
|
