肠黏膜屏障功能评价指标的检测和应用

肠屏障功能障碍是应激状态下导致全身炎性反应综合征、多器官功能障碍综合征甚至多器官功能衰竭的一个重要因素,如何进行肠屏障功能的监测和评估作为研究其发生机制及治疗方法的突破口,已引起广泛关注。现就常用肠屏障功能检测指标:肠黏膜组织学评价、理化特性评价、分子探针检测、D-乳酸监测、细菌移位和内毒素检测等方面予以综述。

The Application of Evaluation Index of Mucosal Barrier Function

Intestinal mucosal barrier dysfunction is an important factor resulting in systemic inflammatory response syndrome、multiple organ dysfunction syndrome and even the multiple organ failure when the body in the stringent state.As the breakthough of researching the mechanism and treatment,how to monitor and evaluate the function of intestinal mucosal barrier has been paid more and more attention.This review provided the progress on the application of the commonly used measures of intestinal mucosal barrier dysfunction,referring to mucosal histology evaluation,evaluation of the physical and chemical properties,molecular probe,D-lactic acid monitoring,detection of bacterial translocation and endotoxin.