丁苯肽软胶囊对大鼠急性脑缺血再灌注损伤脑组织含水及含钙量的影响

目的 研究丁苯肽软胶囊对大鼠急性脑缺血再灌注损伤脑组织含水量及含钙量的影响.方法 选取健康SD大鼠60只,按照随机数字表随机分为6组,采用4血管法造脑缺血再灌注损伤模型,给药组分别给予不同剂量的丁苯肽软胶囊和复方丹参注射液,观察丁苯肽软胶囊对大鼠急性脑缺血再灌注损伤脑组织含水量及含钙量的影响.结果 丁苯肽软胶囊高剂量组可降低大鼠急性脑缺血再灌注损伤脑组织含水量（75.60%）及含钙量（114.53 pg/g）;中剂量组降低大鼠急性脑缺血再灌注损伤脑组织含水量（80.03%）,降低大鼠急性脑缺血再灌注损伤脑组织含钙量（132.33 pg/g）;低剂量组对大鼠急性脑缺血再灌注损伤脑组织含水量（73.93）及含钙量（106.35 pg/g）有降低趋势,但差异无统计学意义（P＞0.05）.结论 丁苯肽软胶囊能降低大鼠急性脑缺血再灌注损伤脑组织含水量及含钙量,具有脑保护作用.

Effects of Butylphthalide soft capsule on water and calcium content in brain tissue of rats with acute cerebral ischemic reperfusion injury

Objective To Study the effects of butylphthalide soft capsule on water and calcium contents in brain tissue of rats with acute cerebral ischemic reperfusion injury. Methods 60 healthy SD rats were randomly divided into 6 groups respectively, sham operation group,model control group,and 4 drug treatment groups. Models of cerebral ischemic reperfusion injury were established by 4 blood--vessel method, and administrated with different doses of butylphthalide soft capsule and compound salvia miltionhiza injection. Effects of butylphthalide soft capsule on water and calcium content in brain tissue of rats with acute cerebral ischemia and reperfution injury were observed. Results Water and calcium content in brain tissue of rats with acute cerebral ischemia reperfusion injury were significantly decreased in butylphthalide soft capsule with high dose group（P~0.01） （water was 75.60~and calcium was114.53 pg/g）. Water and calcium content were also significantly decreased in butylphthalide soft capsule with medium dose group（P〈0.01） （water was 80. 03%and calcium was 132.33 ）. Water and calcium content showed decreasing tendency in butylphthalide soft capsule of low dose group,but without statistical significance,its numerical value was respectively 73.93%and 106.35pg/g. Conclusion Butylphthalide soft capsule can reduce water and calcium content in brain tissue of rats with acute cerebral ischemic reperfusion in- jury,which indicated its neuroprotective effects.