Renieramycin J,a highly cytotoxic tetrahydroisoquinoline alkaloid,from a marine sponge Neopetrosia sp. |
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| Authors: | Oku Naoya Matsunaga Shigeki van Soest Rob W M Fusetani Nobuhiro |
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| Affiliation: | Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. |
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| Abstract: | Renieramycin J (1), a new tetrahydroisoquinoline alkaloid, has been isolated from a marine sponge Neopetrosia sp. as a potent cytotoxin that induced morphological changes in 3Y1 cells. Such changes are characteristic of RNA and/or protein synthesis inhibitors. The structure of 1 including the absolute stereochemistry was determined by spectroscopic and chemical methods. |
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