老年患者使用利奈唑胺致相关性血小板减少症回顾性分析

目的：探讨利奈唑胺在治疗老年人医院获得性感染期间对患者血小板的影响。方法：回顾性分析2010年11月-2012年11月我院使用利奈唑胺（43例）治疗老年人医院获得性感染的临床资料，统计利奈唑胺致相关性血小板减少症发生率、降低幅度、恢复时间等指标，并分析其对治疗的影响。结果：利奈唑胺血小板减少发生率为20．9％，发生在用药后（9．33±3．28）d，血小板水平较用药前下降了（58．8±15．7）％；停用利奈唑胺后（6．44±6．39）d血小板开始上升，（8．83±2．32）d后恢复至用药前水平。结论：利奈唑胺诱导老年人血小板减少为较为常见的药品不良反应，停药后血小板可自行恢复到用药前水平。

Retrospective Analysis of Linezolid-induced Thrombocytopenia in Elderly Patients

OBJECTIVE： To investigate the effect of linezolid on platelet during treatment of hospital-acquired infections in elderly patients. METHODS： A retrospective analysis was performed on the clinical data of 43 elderly patients with hospital-acquired infections treated with linezolid in our hospital from November 2010 to November 2012 with regard to incidence rate of linezolid-induced thrombocytopenia and its reduction rate and recovery time etc as well as its effect on the treatment. RESULTS： Linezolid-induced thrombocytopenia occurred in 20. 9% of the patients at （9.33 ±3.28） days after drug administration; the platelet level decreased by 58.8% ± 15.7% as compared with before administration, but increased at （6.44 ± 6.39） days after discontinuation of linezolid until returned to the level before administration at （ 8.83 ± 2.32 ） days after discontinuation of linezolid. CONCLUSION ： Linezolid-induced thrombocytopenia in the elderly is common adverse drug reactions, and the platelet can automatically return to the level before treatment after withdrawal of linezolid.