热固耦合式超声骨强度仪的可重复性及相关性研究

目的:评估一款国产热固耦合式超声骨强度仪的可重复性和有效性。方法:选择11名志愿者,用该仪器测得右跟骨的两个超声参数,分别是超声速度(SOS)和宽带超声衰减(BUA),计算每个参数的变异系数均方根百分比(CVRMS%),评估该仪器的短期可重复性;选择18名志愿者,用类似的方法评估该仪器的中期可重复性;选择29名志愿者,用双能X线吸收法(DEXA)测量腰椎骨密度(BMD),并与用该仪器测得的跟骨SOS,BUA值进行相关性分析,评估该仪器的有效性。结果:①超声参数SOS,BUA的短期CVRMS%分别为0.30,4.24;中期CVRMS%分别为0.41,4.20。②SOS与腰椎BMD的相关系数r=0.486(P<0.01),BUA与腰椎BMD的相关系数r=0.629(P<0.01)。结论:与国际主流定量超声(QUS)检测仪器相比,热固耦合式超声骨强度仪具有较高的可重复性和准确性,可用于临床骨质状况评估。

Study on the repeatability and correlation of warm-air and solid coupled mode ultrasound bone strength device

Objective:To evaluate the repeatability and correlation of warm-air and solid coupled mode ultrasound bone strength device made in China.Method:Eleven and eighteen volunteers’ right calcaneus ultrasound parameters,speed of sound(SOS)and broadband ultrasound attenuation(BUA),were detected with the device,percentages of root-mean square of coefficient of variation(CVRMS%)of ultrasound parameters were calculated respectively,and used to assess the short-and middle-term repeatability of the device;29 volunteers’ right calcaneus ultrasound parameters(SOS,BUA)were detected with the device and bone mineral density(BMD)of lumbar spine were detected with dual energy X-ray absorptiometry(DEXA).Result:①The short-term CVRMS% were 4.24% for BUA,and 0.30% for SOS;the middle-term CVRMS% were 4.20% for BUA,and 0.41% for SOS.②The correlations between BMD of lumbar spine were 0.629(P<0.01)for BUA and 0.486(P<0.01)for SOS.Conclusion:Compared to international top-grade quantitative ultrasound(QUS)testing device,the warm-air and solid coupled mode ultrasound bone strength device has high performance of repeatability and accuracy,so it can be used to assessing bone mass status.