Correlation in ages at death from familial ovarian cancer among sisters. |
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| Authors: | R S Houlston J Hampson W P Collins M I Whitehead S Campbell J Slack |
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| Affiliation: | Department of Clinical Genetics, Royal Free Hospital School of Medicine, London, United Kingdom. |
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| Abstract: | ![]()
The analysis of pedigrees taken from 97 of 1466 women attending a screening clinic for early familial ovarian cancer showed that there was a strong correlation in the ages at death from the disease among sisters (r = 0.68, confidence limits 0.51-0.82, P < 0.001), but not between mothers and daughters. This information can be used to help counsel women who are considering the appropriate time for more intensive screening or prophylactic oophorectomy. |
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