氟康唑联合定君生治疗复发性外阴阴道假丝酵母菌病102例

目的：观察氟康唑联合定君生治疗复发性外阴阴道假丝酵母菌病的临床疗效。方法：将2011年9月至2013年9月收治的复发性外阴阴道假丝酵母菌病患者随机分为治疗组（102例）和对照组（102例）。治疗组于月经1、4 d 顿服氟康唑 l50 mg/ d，月经干净后定君生塞阴道10 d：对照组仅于月经干净后定君生塞阴道10 d，连续使用3个月经周期。治疗结束后即刻与治疗结束后1个月观察两组的疗效。结果：治疗组治愈90例、好转10例、无效2例，总有效率为98.0％；对照组治愈72例、好转 l8例、无效12例，总有效率为88.2％；两组总有效率比较，差异有统计学意义（P〈0.05）。治疗组治疗完成后1个月复发6例，复发率为6.0％（6/100）；对照组复发13例，复发率为 l4.％（13/90），两组比较，差异有统计学意义（P〈0.05）。结论：氟康唑联合定君生治疗外阴阴道假丝酵母菌病疗效显著，值得临床推广。

102 cases of recurrent vulvovaginal candidiasis treated with fluconazole combined with living preparation of lactobacillus

Objective：To observe the clinical efficiency of treating recurrent vulvovaginal candidiasis using fluconazole combined with Living Preparation of Lactobacillus. Methods： All of the 204 patients who suffered from recurrent vulvovaginal candidiasis between September 2011 and September 2013 were randomly divided into the treatment group（102） and the control group（102）. Patients in the treatment group took fluconazole 150mg/ d on the 2nd and 4th day of menstruation and inserted Living Preparation of Lactobacillus into their vaginas on the 10th day after menstruation while patients in the control group only inserted Living Preparation of Lactobacillus into their vaginas on the 10th day after menstruation, and continuously for 3 menstrual cycles. Consequently, we observed the effectiveness immediately after the end of treatment and one month later.Results：Of the 102 cases in the treatment group, 90 were cured, 10 showed improvement and only 2 were ineffective, and thus the total effective rate reached 98.04%. In the control group, 72 cases were cured, 18 cases showed improvement and 12 cases were ineffective, and the total effective rate was 88.24%. Compare the total efficiency of the two groups and we find out that the difference is statistically significant （P〈0.05）. One month after the completion of treatment, reexamination found 6 cases of recurrence in the treatment group and the recurrence rate was 6%; in the control group, there were 13 cases of recurrence and the recurrence rate was 14.44%. The comparison between the two groups shows the difference is statistically significant （ P 〈 0. 05）. Conclusion： The treatment of recurrent vulvovaginal candidiasis using fluconazole combined with living preparation of lactobacillus is remarkably effective and consequently is worthy of popularization.