Changes of cerebral vasoactive intestinal polypeptide-and somatostatin-like immunoreactivity induced by noise and whole-body vibration in the rat |
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| Authors: | Hiroyuki Nakamura Takashi Moroji Hirofumi Nagase Takao Okazawa Akira Okada |
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| Affiliation: | (1) Department of Public Health, Kanazawa University School of Medicine, 13-1 Takaramachi, 920 Kanazawa, Japan;(2) Department of Psychopharmacology, Psychiatric Research Institute of Tokyo, 2-1-8 Kamikitazawa, 156 Setagaya-ku, Tokyo, Japan |
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| Abstract: | To clarify the role of vasoactive intestinal polypeptide (VIP) and somatostatin, somatropin-release inhibiting factor, (SRIF) neurons in the response to organisms to noise or whole-body vibration stress, VIP and SRIF-like immunoreactivity were determined in various regions of the rat brain following exposure for 90 min to noise (broad band, 102 dB) or whole-body vibration (20 Hz, 4.0 g). Both noise and whole-body vibration significantly increased VIP-like immunoreactivity in the amygdala. A significant reduction of VIP like immunoreactivity in the hippocampus was induced only by whole-body vibration. On the other hand SRIF-like immunoreactivity was decreased significantly in the hypothalamus and increased significantly in the amygdala by noise and whole-body vibration, respectively. The present findings would seem to indicate that the amygdalofugal VIP neural system is involved in regulating hypothalamic and pituitary hormone secretions in non-specific reactions to stress. Responses of hippocampal VIP and the amygdalofugal SRIF to whole-body vibration stress are assumed to be activated as specific reactions to the stress. |
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| Keywords: | Noise Somatostatin Stress Vasoactive intestinal polypeptide Whole-body vibration |
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