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| 粉防己碱对肝纤维化大鼠氨基酸代谢的影响 | |
| 引用本文： | 韩涛,王宝恩,钱绍诚,李冰. 粉防己碱对肝纤维化大鼠氨基酸代谢的影响[J]. 实用肝脏病杂志, 1999, 0(2) |
| 作者姓名： | 韩涛 王宝恩 钱绍诚 李冰 |
| 作者单位： | 北京友谊医院肝病中心，北京友谊医院肝病中心，天津医科大学附属第三中心医院，天津医科大学附属第三中心医院 100050，100050 |
| 摘 要： | 目的 观察粉防己碱对肝纤维化大鼠氨基酸代谢的影响。方法 应用四氯化碳制备大鼠肝纤维化模型。24只雄性SD大鼠随机分为正常对照组、病理对照组和粉防己碱治疗组,每组各8只,实验结束时心脏穿刺取血进行血浆氨基酸分析。结果 粉防己碱治疗组的支╱芳比值明显高于病理对照组。结论 粉防己碱具有改善肝纤维化大鼠氨基酸代谢的作用 |
| 关 键 词： | 粉防已碱 氨基酸代谢 肝纤维化 |
EFFECT OF TETRANDRINE ON SERUM AMINO ACID LEVELS IN CIRRHOTIC RAT |
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| Han Tao,Qian Shaocheng,Wang Baoen,et al.. EFFECT OF TETRANDRINE ON SERUM AMINO ACID LEVELS IN CIRRHOTIC RAT[J]. Journal of Clinical Hepatology, 1999, 0(2) | |
| Authors: | Han Tao Qian Shaocheng Wang Baoen et al. |
| Affiliation: | Han Tao,Qian Shaocheng,Wang Baoen,et al. Liver Disease Research Center,Bejing Friendship Hospital. 100050 |
| Abstract: | Objective To study effect of tetrandrine on serum amino acid levels in fibrotic rat. Methods Liver fibrosis was induced by CCl4 in rat. 24 male SD rats were divided into 3 groups; normal control group,fibrotic control group and tetrandrine-treated group. Results Compared with normal control group,many serum amino acid levels (such as valine,isoleucine,methionine,phenylalanine,histidine, tyrosine and threonine)in fibrotic control group were increased and the ratio of branched chain amino acids/aromatic amino acids(BCAA/AAA)was significantly decreased (P<0.05).On the other hand,the levels of valine and the ratio of BCAA/AAA in tetrandrine-treated group increased and phenylalanine decreased significantly(P<0.05).Conclusions Tetrandrine can improve metabolism of amino acids in fibrotic rat. |
| Keywords: | Liver Fibrosis Tetrandrine Amino Acid Rat |
| 本文献已被 CNKI 等数据库收录！ | |