| 亚低温条件下弥漫性脑损伤海马区凋亡蛋白酶激活因子1蛋白的表达 |
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| 引用本文： | 杨鹏,李云,朱军,李建民,付爱军,刘清军,陈 通,孙泽林,张立民,张云鹤,邹西峰,李群喜.亚低温条件下弥漫性脑损伤海马区凋亡蛋白酶激活因子1蛋白的表达[J].中国神经再生研究,2011,6(11):845-849. |
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| 作者姓名： | 杨鹏 李云 朱军 李建民 付爱军 刘清军 陈 通 孙泽林 张立民 张云鹤 邹西峰 李群喜 |
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| 作者单位： | Peng Yang,Jun Zhu,Jianmin Li,Aijun Fu,Qingjun Liu,Tong Chen,Zelin Sun,Zhiyong Zhang,Limin Zhang,Yunhe Zhang,Xifeng Zou,Qunxi Li(Department of Neurosurgery, Affiliated Hospital of Hebei United University, Tangshan 063007, Hebei Province, China);Yun Li(School of Public Health, Hebei United University, Tangshan 063009, Hebei Province, China) |
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| 基金项目： | a grant from Department of Public Health of Heibei Province, No. 20100134 |
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| 摘 要： | The influence of mild hypothermia on neural cell apoptosis remains poorly understood. Therefore, the present study established rat models of diffuse axonal injury (DAI) at 33 ℃. Morris water maze results demonstrated significantly better learning and memory functions in DAI rats with hypothermia compared with DAI rats with normothermia. Expression of apoptotic protease activating factor-1 in the hippocampal CA1 region was significantly lower in the DAI hypothermia group compared with the DAI normothermia group. Expression of apoptotic protease activating factor-1 positively correlated with latency, but negatively correlated with platform location times and time of swimming in the quadrant area. Results suggested that post-traumatic mild hypothermia in a rat model of DAI could provide cerebral protection by attenuating expression of apoptotic protease activating factor-1.
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| 关 键 词： | diffuse axonal injury hippocampus apoptotic protease activating factor-1 mild hypothermia Morris water maze neural regeneration |
| 收稿时间： | 1/9/2011 12:00:00 AM |
Hippocampal expression of apoptotic protease activating factor-1 following diffuse axonal injury under mild hypothermia |
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| Peng Yang,Yun Li,Jun Zhu,Jianmin Li,Aijun Fu,Qingjun Liu,Tong Chen,Zelin Sun,Zhiyong Zhang,Limin Zhang,Yunhe Zhang,Xifeng Zou,Qunxi Li.Hippocampal expression of apoptotic protease activating factor-1 following diffuse axonal injury under mild hypothermia[J].Neural Regeneration Research,2011,6(11):845-849. |
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| Authors: | Peng Yang Yun Li Jun Zhu Jianmin Li Aijun Fu Qingjun Liu Tong Chen Zelin Sun Zhiyong Zhang Limin Zhang Yunhe Zhang Xifeng Zou Qunxi Li |
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| Institution: | 1Department of Neurosurgery, Affiliated Hospital of Hebei United University, Tangshan 063007, Hebei Province, China 2School of Public Health, Hebei United University, Tangshan 063009, Hebei Province, China |
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| Abstract: | The influence of mild hypothermia on neural cell apoptosis remains poorly understood. Therefore, the present study established rat models of diffuse axonal injury (DAI) at 33 °C. Morris water maze results demonstrated significantly better learning and memory functions in DAI rats with hypothermia compared with DAI rats with normothermia. Expression of apoptotic protease activating factor-1 in the hippocampal CA1 region was significantly lower in the DAI hypothermia group compared with the DAI normothermia group. Expression of apoptotic protease activating factor-1 positively correlated with latency, but negatively correlated with platform location times and time of swimming in the quadrant area. Results suggested that post-traumatic mild hypothermia in a rat model of DAI could provide cerebral protection by attenuating expression of apoptotic protease activating factor-1. |
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| Keywords: | diffuse axonal injury hippocampus apoptotic protease activating factor-1 mild hypothermia Morris water maze neural regeneration |
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