奥拉西坦治疗慢性脑缺血引起的痴呆疗效分析

目的分析奥拉西坦治疗慢性脑缺血引起的痴呆的临床疗效。方法将2010年2月至2011年2月收治的68例由慢性脑缺血引起的痴呆患者随机等分为对照组和观察组，两组均给予常规药物治疗，但观察组加用奥拉西坦；分析两组治疗1个月后的效果，治疗前、治疗后2周和1个月的Barthel指数量表（BI）、长谷川评分（HDS）和简易精神状态评分（MMSE）及血浆神经元特异性烯醇化酶（NSE）水平，并记录治疗期间的不良反应。结果观察组的总有效率高于对照组（97．06％VS．82．35％，P〈0．05），显效率高于对照组（67．65％VS．35．29％，P〈0．01）；治疗后的BI评分、HDS评分和MMSE评分均高于对照组，血浆NSE水平低于对照组，除治疗后1个月的BI评分（P〈0．01）外，其余均为P〈0．05；除观察组的2例胃肠道反应外，两组均未见其他的不良反应。结论奥拉西坦治疗慢性脑缺血引起的痴呆的效果较好，安全性高，可在临床治疗中推广。

Analysis on efficacy of treatment with oxiracetam in patients with chronic cerebral ischemia induced dementia.

Objective To explore the efficacy of oxiracetam in treatment of patients with chronic cerebral ischemia induced dementia. Methods Sixty eight patients with chronic cerebral ischemia induced dementia admitted in this hospital during February 2010 to February 2011 were randomly divided into control group and observation group （n = 34）. Both groups were given with conventional medication, while patients in observation group additionally received oxiracetam treatment. The clinical effects at 1 st month after treatment of both groups were analyzed. Mean- while, the Barthel index scale （ BI）, Hasegawa score （HDS） and mini - mental state score （MMSE） were applied to analyze the effect of treat- ment at 2nd week and 1st month after treatment as well as the plasma neuron - specific enolase level. Adverse reactions during treatment were re- corded. Results The total effective rate （97.06% vs. 82.35%, P 〈0.05） and significant efficiency rate （67.65% vs. 35.29%, P 〈0.01） of observation group were higher than those of control group. The BI, HDS and MMSE scores of observation group after treatment were higher than those of control group as well as the plasma NSE level, and in addition to the BI scores at 1 st month after treatment （ P 〈 0.01 ）, the rest was P 〈 0.05. Besides two eases with gastrointestinal reactions in observation group, patients in both groups showed no other adverse reactions. Conclu- sion The effect of oxiracetam in treatment of patients with chronic cerebral ischemia induced dementia is good with high safety and it is worthy to be recommended.