消化道肿瘤患者化疗后发生口腔感染的影响因素研究

目的探讨消化道肿瘤患者化疗后发生1：7腔感染的危险因素，以期为临床防治提供依据。方法选取2010年1月至2012年12月收治的120例消化道肿瘤化疗患者作为研究对象，进行前瞻性监测研究，对19项口腔感染的可能危险因素进行单因素卡方检验及多因素Logistic回归分析。结果120例消化道肿瘤患者中口腔炎的发生率为37．5％，经单因素分析结果发现年龄、1：2腔环境、口腔自洁习惯、口腔pH值：吸烟、口腔疾患史、含5-Fu／MTX方案、病期、白细胞计数降低度、侵入性操作、化疗周期、义齿与口腔感染发生率有显著相关性（P〈0．05），而性别、Kamofsky评分、焦虑抑郁、有无使用抗生素、上呼吸道感染、职业、文化程度与口腔感染发生率无显著相关性（P〉0．05），以口腔感染发生为因变量，采用非条件Logistic多因素回归分析，结果显示年龄、口腔环境、口腔自洁习惯、白细胞计数、含5-Fu／MTX、病期是消化道瘤患者化疗后口腔感染发生的危险因素（P〈0．05）。结论年龄、白细胞计数、口腔环境、口腔自洁习惯、化疗方案、病期是引发化疗后口腔感染的重要危险因素，临床上可通过正确含漱、科学饮食控制等干预，降低消化道肿瘤患者化疗后口腔感染的发生率。

Study on the influence factors of oral infection to gastrointestinal tumor patients after chemotherapy.

Objective To investigate the risk factors of oral infection to gastrointestinal tumor patients after chemotherapy to provide the basis for clinical prevention and treatment. Methods 120 cases of gastrointestinal tumor chemotherapy patients in our hospital from January 2010 to December 2012 were selected as the research object. 120 cases of chemotherapy patients received the prospective surveillance. 19 survey evalua- tion indexes were taken the single factor chi - square test and the multi - factor Logistic regression analysis. Results The oral cavity inflammation incidence of 80 cases of gastrointestinal tumor patients was 37.5 %. The single factor analysis showed that there was a significant correlation （ P 〈 0.05 ） among age, oral environment, oral self - cleaning habit, pH value, smoking, oral diseases history, scheme of containing 5 - Fu/MTX, disease period, reduction degree of WBC count, invasive operation, chemotherapy cycle, denture with oral infection incidence. While there was no significant correlation （ P 〉 0.05 ） among different sex, Kamofsky score, anxiety and depression, whether using antibiotics, upper respiratory tract infection, occupation, educational level with the incidence of oral infection. If oral infections was selected as the dependent variable, and the re- suits of unconditional Logistic multi- factors regression analysis showed that age, oral environment, oral self- cleaning habit, white blood cell count, containing 5 - Fu/MTX, disease period are the risk factors of oral infections （ P 〈 0.05 ） to gastrointestinal tumor patients after chemother- apy. Conclusions The age, white blood cell count, oral environment, oral self - cleaning habit, chemotherapy regimens, disease period are the important risk factors to trigger oral infection after chemotherapy. In clinic, the interventions of correct contain gargle, scientific diet controlling can be used to reduce the incidence of oral infection to gastrointestinal tumor patients after chemotherapy.