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| 铅镉砷联合毒物对人体免疫功能影响的流行病学研究 | |
| 引用本文： | 周勇,胡建安,张辉,周少平. 铅镉砷联合毒物对人体免疫功能影响的流行病学研究[J]. 湘南学院学报(医学版), 2007, 9(1): 26-28 |
| 作者姓名： | 周勇 胡建安 张辉 周少平 |
| 作者单位： | 1. 中南大学公共卫生学院,湖南,长沙,410078;湘南学院预防医学教研室,湖南,郴州,423000 2. 中南大学公共卫生学院,湖南,长沙,410078 3. 湘南学院化学与生命科学院 4. 湘南学院预防医学教研室,湖南,郴州,423000 |
| 基金项目： | 湖南省卫生厅药卫生科学技术研究课题 |
| 摘 要： | 目的 探讨铅镉砷联合毒物对机体免疫功能的影响。方法 选择48名重金属中毒的矿工作为毒物组、48名同期住院病人作为对照组，分别检测患者血、尿铅、镉、砷含量，及血免疫球蛋白含量。结果 毒物组血、尿铅、镉、砷含量较对照组显著升高（P〈0．01）。与对照组比较，毒物组IgG、IgM浓度下降（P〈0．01），而IgA浓度则升高（P〈0．01）。结论 铅镉砷联合毒物损伤了机体的免疫功能。患者血液中免疫球蛋白含量能够作为铅镉砷混合物中毒的灵敏的早期诊断指标。 |
| 关 键 词： | 铅 镉 砷 混合物 免疫功能 免疫毒性 |
| 文章编号： | 24350674 |
| 修稿时间： | 2006-09-15 |
An Epidemiological Study on the Effect of Lead-cadmium-arsenic Mixture in Immunological Function |
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| ZHOU Yong, HU Jian-an, ZHANG Hui, et al. An Epidemiological Study on the Effect of Lead-cadmium-arsenic Mixture in Immunological Function[J]. JOurnal of Xiangnan University(Medical Sciences), 2007, 9(1): 26-28 | |
| Authors: | ZHOU Yong HU Jian-an ZHANG Hui et al |
| Affiliation: | School of Public Health, Central South University, Changsha, Hunan 410078, China |
| Abstract: | Objective To examine the effect of lead-cadmium-arsenic mixture in immunological function of humans.Methods 48 miners of heavy metal poisoning were chosen as poison group,and another 48 synchronous inpatient were chosen as contrast group.The content of lead,cadmium,arsenic in blood and urine and immunoglobulin in blood was respectively detected.Results The content of lead,cadmium,arsenic in blood and urine of poison group have significant increased to compare with contrast group(P<0.01).The content of IgG and IgM have respectively decreased,while the content of IgA has increased,it had a remarkably significance compared with contrast group(P<0.01).Conclusion The lead-cadmium-arsenic mixture damaged immunological function of humans,Immunoglobulin might use as sensitive diagnostic criteria in earlier period of lead-cadmium-arsenic mixture poisoning. |
| Keywords: | Lead Cadmium Arsenic Mixture Immunological function Immunotoxicity |
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